biostudies-literatureMassaoudi YUnitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii8852418https://www.ebi.ac.uk/biostudies/studies/S-EPMC7707988biostudies-literatureUnknown2020Recently, the implication of oxidative stress in behavioral-like disorders has received a lot of attention. Many studies were interested in searching for new natural compounds with protective effects on behavioral-like disorders by focusing on oxidative stress as the main causal factor. Here, we assess the potential effect of cell-free extracts from halophilic bacteria on memory, anxiety, and depression-related behaviors in mice, as well as on cognitive deficits, negative symptoms, and some oxidative stress biomarkers in methionine-induced mice models of schizophrenia. Firstly, crude extracts of bacteria isolated from the Dead Sea were screened for their effects on memory and anxiety- and depression-like behaviors through Y-maze, elevated plus maze, and forced swimming test, respectively, Evidence-based complementary and alternative medicine : eCAMProtective Effects of Two Halophilic Crude Extracts from <i>Pseudomonas zhaodongensis</i> and <i>Bacillus stratosphericus</i> against Memory Deficits and Anxiety- and Depression-Like Behaviors in Methionine-Induced Schizophrenia in Mice Focusing on Oxidative Stress Status.PMC7707988PN-III-P1-1.1-TE-2016-1210Sendide KAnissi JCiobica AMassaoudi YLefter RHassouni MELobiuc AfalseProtective Effects of Two Halophilic Crude Extracts from <i>Pseudomonas zhaodongensis</i> and <i>Bacillus stratosphericus</i> against Memory Deficits and Anxiety- and Depression-Like Behaviors in Methionine-Induced Schizophrenia in Mice Focusing on Oxidative Stress Status.Recently, the implication of oxidative stress in behavioral-like disorders has received a lot of attention. Many studies were interested in searching for new natural compounds with protective effects on behavioral-like disorders by focusing on oxidative stress as the main causal factor. Here, we assess the potential effect of cell-free extracts from halophilic bacteria on memory, anxiety, and depression-related behaviors in mice, as well as on cognitive deficits, negative symptoms, and some oxidative stress biomarkers in methionine-induced mice models of schizophrenia. Firstly, crude extracts of bacteria isolated from the Dead Sea were screened for their effects on memory and anxiety- and depression-like behaviors through Y-maze, elevated plus maze, and forced swimming test, respectively, 2020-01-01T00:00:00Z20202025-04-18T11:31:41.044Z2021-02-20T10:35:30ZS-EPMC77079883329946110.1155/2020/8852418