{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["National Natural Science Foundation of China"],"pagination":["9196379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7707998"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2020"],"pubmed_abstract":["<h4>Background</h4>Untreated nephropathy can progress to renal failure. The traditional Mongolian remedy Narenmandula regulates the kidney \"yang.\" This study aimed to identify key microRNAs (miRNAs) targeted by Narenmandula in a rat model of nephropathy.<h4>Methods</h4>Fifteen rats exhibiting normal renal function were randomized to three study arms. Nephropathy was induced in <i>n</i> = 10 rats using doxorubicin hydrochloride, followed by either Narenmandula treatment (treatment group) or no treatment (control group). In <i>n</i> = 5 rats, no doxorubicin was given and renal function remained unchanged (healthy group). Microarray analysis identified miRNAs which were differentially expressed (DE-miRNAs) between groups. Target genes of DE-miRNAs were predicted using miRWalk version 2.0, fol"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Identifying Key MicroRNAs Targeted by Narenmandula in a Rodent Nephropathy Model."],"pmcid":["PMC7707998"],"funding_grant_id":["81641149"],"pubmed_authors":["Aodaofu A","Liu X","Jin W","Arun A","Sudunabuqi S","Wang X","Chang C","Chen H","Wu F"],"additional_accession":[]},"is_claimable":false,"name":"Identifying Key MicroRNAs Targeted by Narenmandula in a Rodent Nephropathy Model.","description":"<h4>Background</h4>Untreated nephropathy can progress to renal failure. The traditional Mongolian remedy Narenmandula regulates the kidney \"yang.\" This study aimed to identify key microRNAs (miRNAs) targeted by Narenmandula in a rat model of nephropathy.<h4>Methods</h4>Fifteen rats exhibiting normal renal function were randomized to three study arms. Nephropathy was induced in <i>n</i> = 10 rats using doxorubicin hydrochloride, followed by either Narenmandula treatment (treatment group) or no treatment (control group). In <i>n</i> = 5 rats, no doxorubicin was given and renal function remained unchanged (healthy group). Microarray analysis identified miRNAs which were differentially expressed (DE-miRNAs) between groups. Target genes of DE-miRNAs were predicted using miRWalk version 2.0, fol","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-18T11:33:01.991Z","creation":"2021-02-20T10:35:32Z"},"accession":"S-EPMC7707998","cross_references":{"pubmed":["33299464"],"doi":["10.1155/2020/9196379"]}}