{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kolenko P"],"funding":["Akademie Věd České Republiky","Ministerstvo Školství, Mládeže a Tělovýchovy","České Vysoké Učení Technické v Praze"],"pagination":["1233-1243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7709200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(Pt 12)"],"pubmed_abstract":["Solution and crystal data are reported for DNA 18-mers with sequences related to those of bacterial noncoding single-stranded DNA segments called repetitive extragenic palindromes (REPs). Solution CD and melting data showed that the CG-rich, near-palindromic REPs from various bacterial species exhibit dynamic temperature-dependent and concentration-dependent equilibria, including architectures compatible with not only hairpins, which are expected to be biologically relevant, but also antiparallel duplexes and bimolecular tetraplexes. Three 18-mer oligonucleotides named Hpar-18 (PDB entry 6rou), Chom-18 (PDB entry 6ros) and its brominated variant Chom-18Br (PDB entry 6ror) crystallized as isomorphic right-handed A-like duplexes. The low-resolution crystal structures were solved with the hel"],"journal":["Acta crystallographica. Section D, Structural biology"],"pubmed_title":["Structural variability of CG-rich DNA 18-mers accommodating double T-T mismatches."],"pmcid":["PMC7709200"],"funding_grant_id":["LTAUSA18197","LM2018127","LM2015043","SGS19/189/OHK4/3T/14","CZ.02.1.01/0.0/0.0/16_013/0001776","RVO 86652036","CZ.1.05/1.1.00/02.0109"],"pubmed_authors":["Cerny J","Svoboda J","Schneider B","Charnavets T","Kolenko P"],"additional_accession":[]},"is_claimable":false,"name":"Structural variability of CG-rich DNA 18-mers accommodating double T-T mismatches.","description":"Solution and crystal data are reported for DNA 18-mers with sequences related to those of bacterial noncoding single-stranded DNA segments called repetitive extragenic palindromes (REPs). Solution CD and melting data showed that the CG-rich, near-palindromic REPs from various bacterial species exhibit dynamic temperature-dependent and concentration-dependent equilibria, including architectures compatible with not only hairpins, which are expected to be biologically relevant, but also antiparallel duplexes and bimolecular tetraplexes. Three 18-mer oligonucleotides named Hpar-18 (PDB entry 6rou), Chom-18 (PDB entry 6ros) and its brominated variant Chom-18Br (PDB entry 6ror) crystallized as isomorphic right-handed A-like duplexes. The low-resolution crystal structures were solved with the hel","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-04-30T08:10:03.068Z","creation":"2026-04-07T15:56:46.715Z"},"accession":"S-EPMC7709200","cross_references":{"pubmed":["33263329"],"doi":["10.1107/S2059798320014151"]}}