{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Imbir G"],"funding":["European Social Fund"],"pagination":["E859"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7712484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(5)"],"pubmed_abstract":["Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the urgent need for functional blood-contacting coatings. The properties of PEMs can be easily tuned in order to provide a scaffold with desired physico-chemical parameters. In this study chitosan/chondroitin sulfate (Chi/CS) polyelectrolyte multilayers were deposited on medical polyurethane. Afterwards PEMs were modified by chemical cross-linking and nanoparticles introduction. Coatings with variable properties were tested for their hemocompatibility in the cone-plate tester under dynamic conditions. The obtained results enable the understanding of how substrate properties modulate PEMs interaction with blood plasma proteins and the morphotic elements."],"journal":["Nanomaterials (Basel, Switzerland)"],"pubmed_title":["Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow."],"pmcid":["PMC7712484"],"funding_grant_id":["WND-POWR.03.02.00-00-I043/16"],"pubmed_authors":["Imbir G","Mzyk A","Major R","Trembecka-Wojciga K","Plutecka H","Schirhagl R","Jasek-Gajda E"],"additional_accession":[]},"is_claimable":false,"name":"Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow.","description":"Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the urgent need for functional blood-contacting coatings. The properties of PEMs can be easily tuned in order to provide a scaffold with desired physico-chemical parameters. In this study chitosan/chondroitin sulfate (Chi/CS) polyelectrolyte multilayers were deposited on medical polyurethane. Afterwards PEMs were modified by chemical cross-linking and nanoparticles introduction. Coatings with variable properties were tested for their hemocompatibility in the cone-plate tester under dynamic conditions. The obtained results enable the understanding of how substrate properties modulate PEMs interaction with blood plasma proteins and the morphotic elements.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2024-02-15T07:29:50.801Z","creation":"2021-02-20T02:56:23Z"},"accession":"S-EPMC7712484","cross_references":{"pubmed":["32365586"],"doi":["10.3390/nano10050859"]}}