{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang Q"],"funding":["Science and Technology Commission of Shanghai Municipality","National Key Research and Development Program of China Stem Cell and Translational Research"],"pagination":["597702"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7713593"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Recently, a growing number of studies focus on partial tumor irradiation to induce the stronger non-target effects. However, the value of partial volume carbon ion radiotherapy (CIRT) targeting hypoxic region of a tumor under imaging guidance as well as its effect of inducing radiation induced abscopal effects (RIAEs) have not been well investigated. Herein, we developed a technique of carbon ion microporous radiation (CI-MPR), guided by <sup>18</sup>F-FMISO PET/computerized tomography (CT), for partial volume radiation targeting the hypoxia area of a tumor and investigated its capability of inducing abscopal effects. Tumor-bearing mice were inoculated subcutaneously with breast cancer 4T1 cells into the flanks of both hind legs of mouse. Mice were assigned to three groups: group I: contro"],"journal":["Frontiers in oncology"],"pubmed_title":["Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation."],"pmcid":["PMC7713593"],"funding_grant_id":["2018YFC0115700","18XD1423000"],"pubmed_authors":["Yang J","Kong L","Lu JJ","Huang Y","Wang W","Huang Q","Lin LC","Sun Y","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation.","description":"Recently, a growing number of studies focus on partial tumor irradiation to induce the stronger non-target effects. However, the value of partial volume carbon ion radiotherapy (CIRT) targeting hypoxic region of a tumor under imaging guidance as well as its effect of inducing radiation induced abscopal effects (RIAEs) have not been well investigated. Herein, we developed a technique of carbon ion microporous radiation (CI-MPR), guided by <sup>18</sup>F-FMISO PET/computerized tomography (CT), for partial volume radiation targeting the hypoxia area of a tumor and investigated its capability of inducing abscopal effects. Tumor-bearing mice were inoculated subcutaneously with breast cancer 4T1 cells into the flanks of both hind legs of mouse. Mice were assigned to three groups: group I: contro","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-19T14:00:49.606Z","creation":"2021-02-20T16:40:56Z"},"accession":"S-EPMC7713593","cross_references":{"pubmed":["33330089"],"doi":["10.3389/fonc.2020.597702"]}}