{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dean KR"],"funding":["United States Department of Defense | United States Army | U.S. Army Research, Development and Engineering Command | Army Research Office"],"pagination":["3337-3349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7714692"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(12)"],"pubmed_abstract":["Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, and organism-level physiological changes. Identification of these signals could aid in diagnostics, treatment decision-making, and risk evaluation. In the search for PTSD diagnostic biomarkers, we ascertained over one million molecular, cellular, physiological, and clinical features from three cohorts of male veterans. In a discovery"],"journal":["Molecular psychiatry"],"pubmed_title":["Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder."],"pmcid":["PMC7714692"],"funding_grant_id":["W911NF-17-2-0086","W911NF-18-2-0056","W911NF-17-1-0069","W911NF-13-1-0376"],"pubmed_authors":["Gautam A","Jett M","Siegel C","Wu C","Hoke A","Young Lee M","Wu G","Baxter D","Wang K","Kumar R","Bersani FS","Flory JD","Petzold L","Desarnaud F","Yehuda R","Laska E","Wu X","Abu-Amara D","Misganaw B","Bierer L","Newman J","Almli LM","Marmar C","Li M","Lu L","Dean KR","Guffanti G","Thakur GS","Yang R","Lori A","PTSD Systems Biology Consortium","Chakraborty N","Muhie S","Coy M","Price ND","Reus VI","Scherler K","Wolkowitz OM","Hood L","Blessing E","Miller SA","Lee I","Qin S","Ressler KJ","Tang L","Cho JH","Mellon SH","Srinivasan S","Suessbrick A","Doyle FJ","Hammamieh R","Kerley K","Price L","Daigle BJ","Makotkine I","Donohue D","Zhou Y","Lindqvist D","Fossati S","Somvanshi PR","Kim TK","Qian M"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.","description":"Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, and organism-level physiological changes. Identification of these signals could aid in diagnostics, treatment decision-making, and risk evaluation. In the search for PTSD diagnostic biomarkers, we ascertained over one million molecular, cellular, physiological, and clinical features from three cohorts of male veterans. In a discovery","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-19T10:36:28.863Z","creation":"2021-02-20T10:05:29Z"},"accession":"S-EPMC7714692","cross_references":{"pubmed":["31501510"],"doi":["10.1038/s41380-019-0496-z"]}}