biostudies-literatureDean KRUnited States Department of Defense | United States Army | U.S. Army Research, Development and Engineering Command | Army Research Office3337-3349https://www.ebi.ac.uk/biostudies/studies/S-EPMC7714692biostudies-literatureUnknown25(12)Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, and organism-level physiological changes. Identification of these signals could aid in diagnostics, treatment decision-making, and risk evaluation. In the search for PTSD diagnostic biomarkers, we ascertained over one million molecular, cellular, physiological, and clinical features from three cohorts of male veterans. In a discoveryMolecular psychiatryMulti-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.PMC7714692W911NF-17-2-0086W911NF-18-2-0056W911NF-17-1-0069W911NF-13-1-0376Gautam AJett MSiegel CWu CHoke AYoung Lee MWu GBaxter DWang KKumar RBersani FSFlory JDPetzold LDesarnaud FYehuda RLaska EWu XAbu-Amara DMisganaw BBierer LNewman JAlmli LMMarmar CLi MLu LDean KRGuffanti GThakur GSYang RLori APTSD Systems Biology ConsortiumChakraborty NMuhie SCoy MPrice NDReus VIScherler KWolkowitz OMHood LBlessing EMiller SALee IQin SRessler KJTang LCho JHMellon SHSrinivasan SSuessbrick ADoyle FJHammamieh RKerley KPrice LDaigle BJMakotkine IDonohue DZhou YLindqvist DFossati SSomvanshi PRKim TKQian MfalseMulti-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, and organism-level physiological changes. Identification of these signals could aid in diagnostics, treatment decision-making, and risk evaluation. In the search for PTSD diagnostic biomarkers, we ascertained over one million molecular, cellular, physiological, and clinical features from three cohorts of male veterans. In a discovery2020-01-01T00:00:00Z2020 Dec2025-04-19T10:36:28.863Z2021-02-20T10:05:29ZS-EPMC77146923150151010.1038/s41380-019-0496-z