biostudies-literaturePadmini RMinistry of EducationMinistry of Science, ICT and Future PlanningNational Research Foundation of KoreaKing Saud University3274-3289https://www.ebi.ac.uk/biostudies/studies/S-EPMC7715046biostudies-literatureUnknown27(12)Garlic (<i>Allium sativum</i> L.), is a predominant spice, which is used as an herbal medicine and flavoring agent, since ancient times. It has a rich source of various secondary metabolites such as flavonoids, terpenoids and alkaloids, which have various pharmacological properties. Garlic is used in the treatment of various ailments such as cancer, diabetes and cardiovascular diseases. The present study aims to explore the plausible mechanisms of the selected phytocompounds as potential inhibitors against the known drug targets of non-small-cell lung cancer (NSCLC). The phytocompounds of garlic were identified by gas chromatography-mass spectrometry (GC-MS) technique. Subsequently, the identified phytocompounds were subjected to molecular docking to predict the binding with the drug targeSaudi journal of biological sciencesIdentification of novel bioactive molecules from garlic bulbs: A special effort to determine the anticancer potential against lung cancer with targeted drugs.PMC7715046NRF-2018M3A9A7057263Alwahibi MSPadmini RSaravanan POck Kim YKim HKim HJRavindran BUma Maheshwari VRazia MSoliman Elshikh MWoo Lee KfalseIdentification of novel bioactive molecules from garlic bulbs: A special effort to determine the anticancer potential against lung cancer with targeted drugs.Garlic (<i>Allium sativum</i> L.), is a predominant spice, which is used as an herbal medicine and flavoring agent, since ancient times. It has a rich source of various secondary metabolites such as flavonoids, terpenoids and alkaloids, which have various pharmacological properties. Garlic is used in the treatment of various ailments such as cancer, diabetes and cardiovascular diseases. The present study aims to explore the plausible mechanisms of the selected phytocompounds as potential inhibitors against the known drug targets of non-small-cell lung cancer (NSCLC). The phytocompounds of garlic were identified by gas chromatography-mass spectrometry (GC-MS) technique. Subsequently, the identified phytocompounds were subjected to molecular docking to predict the binding with the drug targe2020-01-01T00:00:00Z2020 Dec2025-04-18T20:41:01.109Z2021-02-20T10:54:28ZS-EPMC77150463330413310.1016/j.sjbs.2020.09.041