{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["35(12)"],"submitter":["Levin A"],"funding":["Inga-Britt and Arne Lundberg Research Foundation","Strategic Research Program in Diabetes at Karolinska Institutet, Center for Innovative Medicine","Sahlgrenska University Hospital ALF Grant","Swedish Kidney Foundation","Karolinska Institutet","Margaretha af Ugglas Foundation","AstraZeneca","Swedish Research Council","Stockholm County Council"],"pubmed_abstract":["<h4>Background</h4>Diabetic nephropathy (DN) is the most common cause of end-stage renal disease, affecting ∼30% of the rapidly growing diabetic population, and strongly associated with cardiovascular risk. Despite this, the molecular mechanisms of disease remain unknown.<h4>Methods</h4>RNA sequencing (RNAseq) was performed on paired, micro-dissected glomerular and tubulointerstitial tissue from patients diagnosed with DN [n = 19, 15 males, median (range) age: 61 (30-85) years, chronic kidney disease stages 1-4] and living kidney donors [n = 20, 12 males, median (range) age: 56 (30-70) years].<h4>Results</h4>Principal component analysis showed a clear separation between glomeruli and tubulointerstitium transcriptomes. Differential expression analysis identified 1550 and 4530 differentially"],"journal":["Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association"],"pagination":["2059-2072"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7716805"],"repository":["biostudies-literature"],"pubmed_title":["Novel insights into the disease transcriptome of human diabetic glomeruli and tubulointerstitium."],"pmcid":["PMC7716805"],"pubmed_authors":["Levin A","Blondal T","Erlandsson F","Ebefors K","Liu P","Nordstrom J","Zambrano S","Stenvinkel P","Witasp A","Nystrom J","Wernerson A","Reznichenko A","Greasley PJ","Barany P","Patrakka J","Sorrentino A","Bruchfeld A"],"additional_accession":[]},"is_claimable":false,"name":"Novel insights into the disease transcriptome of human diabetic glomeruli and tubulointerstitium.","description":"<h4>Background</h4>Diabetic nephropathy (DN) is the most common cause of end-stage renal disease, affecting ∼30% of the rapidly growing diabetic population, and strongly associated with cardiovascular risk. Despite this, the molecular mechanisms of disease remain unknown.<h4>Methods</h4>RNA sequencing (RNAseq) was performed on paired, micro-dissected glomerular and tubulointerstitial tissue from patients diagnosed with DN [n = 19, 15 males, median (range) age: 61 (30-85) years, chronic kidney disease stages 1-4] and living kidney donors [n = 20, 12 males, median (range) age: 56 (30-70) years].<h4>Results</h4>Principal component analysis showed a clear separation between glomeruli and tubulointerstitium transcriptomes. Differential expression analysis identified 1550 and 4530 differentially","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-06-01T01:55:01.549Z","creation":"2025-06-01T01:55:01.549Z"},"accession":"S-EPMC7716805","cross_references":{"pubmed":["32853351"],"doi":["10.1093/ndt/gfaa121"]}}