biostudies-literatureBao BNCI NIH HHSThe Believe Foundation and Joann M. Deliz and James W. Deliz in memory of David BergmanNIH NCI1803-1814https://www.ebi.ac.uk/biostudies/studies/S-EPMC7718329biostudies-literatureUnknown18(12)Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks expression of estrogen receptor, progesterone receptor, and the HER2 but is enriched with cancer stem cell-like cells (CSC). CSCs are the fraction of cancer cells recognized as the source of primary malignant tumors that also give rise to metastatic recurrence. 5-Hydroxymethylcytosine (5hmC) is a DNA epigenetic feature derived from 5-methylcytosine by action of tet methylcytosine dioxygenase enzymes (e.g., TET1); and although TET1 and 5hmC are required to maintain embryonic stem cells, the mechanism and role in CSCs remain unknown. Data presented in this report support the conclusion that TET1 and TET1-dependent 5hmC mediate hydrogen peroxide (H₂O₂)-dependent activation of a novel gene expreMolecular cancer research : MCRRole of TET1 and 5hmC in an Obesity-Linked Pathway Driving Cancer Stem Cells in Triple-Negative Breast Cancer.PMC7718329P30 CA022453P30CA022453Boerner JLBollig-Fischer AMitrea CBao BDyson GTeslow EAfalseRole of TET1 and 5hmC in an Obesity-Linked Pathway Driving Cancer Stem Cells in Triple-Negative Breast Cancer.Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks expression of estrogen receptor, progesterone receptor, and the HER2 but is enriched with cancer stem cell-like cells (CSC). CSCs are the fraction of cancer cells recognized as the source of primary malignant tumors that also give rise to metastatic recurrence. 5-Hydroxymethylcytosine (5hmC) is a DNA epigenetic feature derived from 5-methylcytosine by action of tet methylcytosine dioxygenase enzymes (e.g., TET1); and although TET1 and 5hmC are required to maintain embryonic stem cells, the mechanism and role in CSCs remain unknown. Data presented in this report support the conclusion that TET1 and TET1-dependent 5hmC mediate hydrogen peroxide (H₂O₂)-dependent activation of a novel gene expre2020-01-01T00:00:00Z2020 Dec2026-04-29T01:05:12.648Z2022-02-10T13:06:31.709ZS-EPMC77183293291311110.1158/1541-7786.MCR-20-035910.1158/1541-7786.mcr-20-0359