{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gordon AC"],"funding":["Robert H Lurie Comprehensive Cancer Center Pathology Core Facility","ACG Medical Scientist Training Program","Investigator Initiated Study","SIR Foundation Allied Scientist Grant","Department of Radiology of the Feinberg School of Medicine","NCI NIH HHS","RSNA Foundation Research Scholar Grant","NIH","Northwestern University Mouse Histology and Phenotyping Laboratory which is supported by NCI","NIGMS NIH HHS"],"pagination":["849-858"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7719607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(6)"],"pubmed_abstract":["<h4>Rationale and objectives</h4>To use a rapid gas-challenge blood oxygen-level dependent magnetic resonance imaging exam to evaluate changes in tumor hypoxia after <sup>90</sup>Y radioembolization (Y90) in the VX2 rabbit model.<h4>Materials and methods</h4>White New Zealand rabbits (n = 11) provided a Y90 group (n = 6 rabbits) and untreated control group (n = 5 rabbits). R2* maps were generated with gas-challenges (O<sub>2</sub>/room air) at baseline, 1 week, and 2 weeks post-Y90. Laboratory toxicity was evaluated at baseline, 24 hours, 72 hours, 1 hours, and 2 weeks. Histology was used to evaluate tumor necrosis on hematoxylin and eosin and immunofluorescence imaging was used to assess microvessel density (CD31) and proliferative index (Ki67).<h4>Results</h4>At baseline, median tumor vo"],"journal":["Academic radiology"],"pubmed_title":["Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma."],"pmcid":["PMC7719607"],"funding_grant_id":["CA126809","T32 GM008152","R01 CA126809","P30 CA060553","R25 CA132822","5R25 CA 132822-03","T32GM008152","R01 CA209886","P30-CA060553","U54 CA199091","R01 CA241532"],"pubmed_authors":["Lewandowski RJ","Gates VL","White SB","Omary RA","Li W","Yang Y","Salem R","Procissi D","Zhang Z","Huang X","Harris KR","Larson AC","Lyu T","Gordon AC"],"additional_accession":[]},"is_claimable":false,"name":"Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma.","description":"<h4>Rationale and objectives</h4>To use a rapid gas-challenge blood oxygen-level dependent magnetic resonance imaging exam to evaluate changes in tumor hypoxia after <sup>90</sup>Y radioembolization (Y90) in the VX2 rabbit model.<h4>Materials and methods</h4>White New Zealand rabbits (n = 11) provided a Y90 group (n = 6 rabbits) and untreated control group (n = 5 rabbits). R2* maps were generated with gas-challenges (O<sub>2</sub>/room air) at baseline, 1 week, and 2 weeks post-Y90. Laboratory toxicity was evaluated at baseline, 24 hours, 72 hours, 1 hours, and 2 weeks. Histology was used to evaluate tumor necrosis on hematoxylin and eosin and immunofluorescence imaging was used to assess microvessel density (CD31) and proliferative index (Ki67).<h4>Results</h4>At baseline, median tumor vo","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-21T21:24:30.999Z","creation":"2025-04-05T18:22:16.121Z"},"accession":"S-EPMC7719607","cross_references":{"pubmed":["32522403"],"doi":["10.1016/j.acra.2020.04.012"]}}