biostudies-literatureWang PHMinistry of Health and Welfare21367https://www.ebi.ac.uk/biostudies/studies/S-EPMC7721715biostudies-literatureUnknown10(1)A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT-Plus) may have better positive consistency, but this needs to be investigated. We enrolled dialysis patients with baseline positive QFT-GIT<sub>0</sub> results and conducted two rounds of follow-up paired QFT-GIT<sub>1&2</sub> and QFT-Plus<sub>1&2</sub> tests at an interval of 6 months. The positive consistency, concordance, and discordance of the QFT results were analyzed. A total of 236 patients on dialysis were screened, and 73 participants with positive QFT-GIT<sub>0</sub> results were enrolled. The baseline QFT-GIT<sub>0</sub> response was higher in the 1st QFT-Plus<sub>1</sub>(Scientific reportsCD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis.PMC7721715107-TDU-B-211-123002, 108-TDU-B-211-133002Yu CJShu CCWang PHLee CYWei YFLin SWLee SSWang JYLin SYfalseCD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis.A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT-Plus) may have better positive consistency, but this needs to be investigated. We enrolled dialysis patients with baseline positive QFT-GIT<sub>0</sub> results and conducted two rounds of follow-up paired QFT-GIT<sub>1&2</sub> and QFT-Plus<sub>1&2</sub> tests at an interval of 6 months. The positive consistency, concordance, and discordance of the QFT results were analyzed. A total of 236 patients on dialysis were screened, and 73 participants with positive QFT-GIT<sub>0</sub> results were enrolled. The baseline QFT-GIT<sub>0</sub> response was higher in the 1st QFT-Plus<sub>1</sub>(2020-01-01T00:00:00Z2020 Dec2025-04-26T14:45:07.699Z2025-04-06T14:40:47.73ZS-EPMC77217153328881410.1038/s41598-020-78374-3