{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ariyasingha NM"],"funding":["Russian Ministry of Science and Higher Education","National Heart, Lung, and Blood Institute (NHLBI) - NIH","Congressionally Directed Medical Research Programs","Directorate for Mathematical and Physical Sciences","NHLBI NIH HHS","Russian Foundation for Basic Research","Russian Science Foundation","Russian Foundation for Basic Research (RFBR)"],"pagination":["13621-13626"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7722203"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(60)"],"pubmed_abstract":["The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear spin hyperpolarized gas as a contrast agent. The long gas-phase lifetimes of hyperpolarized <sup>129</sup> Xe make this inhalable contrast agent acceptable for clinical research today despite limitations such as high cost, low throughput of production and challenges of <sup>129</sup> Xe imaging on clinical MRI scanners, which are normally equipped with proton detection only. We report on low-cost and high-throughput preparation of proton-hyperpolarized diethyl ether, which can be potentially employed for pulmonary imaging with a nontoxic, simple, and sensitive overall strategy using proton detection commonly available on all clinical MRI scanners. Diethyl ether is hype"],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Parahydrogen-Induced Polarization of Diethyl Ether Anesthetic."],"pmcid":["PMC7722203"],"funding_grant_id":["AAAA-A16-116121510087-5","19-13-00172","19-33-60045","R21HL154032","17-54-33037","W81XWH-15-1-0271","CHE-1904780","19-53-12013","R21 HL154032"],"pubmed_authors":["Chukanov NV","Bukhtiyarov VI","Joalland B","Younes HR","Chekmenev EY","Ariyasingha NM","Kovtunov KV","Gelovani JG","Koptyug IV","Salnikov OG","Kovtunova LM"],"additional_accession":[]},"is_claimable":false,"name":"Parahydrogen-Induced Polarization of Diethyl Ether Anesthetic.","description":"The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear spin hyperpolarized gas as a contrast agent. The long gas-phase lifetimes of hyperpolarized <sup>129</sup> Xe make this inhalable contrast agent acceptable for clinical research today despite limitations such as high cost, low throughput of production and challenges of <sup>129</sup> Xe imaging on clinical MRI scanners, which are normally equipped with proton detection only. We report on low-cost and high-throughput preparation of proton-hyperpolarized diethyl ether, which can be potentially employed for pulmonary imaging with a nontoxic, simple, and sensitive overall strategy using proton detection commonly available on all clinical MRI scanners. Diethyl ether is hype","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-04T01:43:01.212Z","creation":"2025-04-04T01:43:01.212Z"},"accession":"S-EPMC7722203","cross_references":{"pubmed":["32667687"],"doi":["10.1002/chem.202002528"]}}