biostudies-literatureAriyasingha NMRussian Ministry of Science and Higher EducationNational Heart, Lung, and Blood Institute (NHLBI) - NIHCongressionally Directed Medical Research ProgramsDirectorate for Mathematical and Physical SciencesNHLBI NIH HHSRussian Foundation for Basic ResearchRussian Science FoundationRussian Foundation for Basic Research (RFBR)13621-13626https://www.ebi.ac.uk/biostudies/studies/S-EPMC7722203biostudies-literatureUnknown26(60)The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear spin hyperpolarized gas as a contrast agent. The long gas-phase lifetimes of hyperpolarized ¹²⁹ Xe make this inhalable contrast agent acceptable for clinical research today despite limitations such as high cost, low throughput of production and challenges of ¹²⁹ Xe imaging on clinical MRI scanners, which are normally equipped with proton detection only. We report on low-cost and high-throughput preparation of proton-hyperpolarized diethyl ether, which can be potentially employed for pulmonary imaging with a nontoxic, simple, and sensitive overall strategy using proton detection commonly available on all clinical MRI scanners. Diethyl ether is hypeChemistry (Weinheim an der Bergstrasse, Germany)Parahydrogen-Induced Polarization of Diethyl Ether Anesthetic.PMC7722203AAAA-A16-116121510087-519-13-0017219-33-60045R21HL15403217-54-33037W81XWH-15-1-0271CHE-190478019-53-12013R21 HL154032Chukanov NVBukhtiyarov VIJoalland BYounes HRChekmenev EYAriyasingha NMKovtunov KVGelovani JGKoptyug IVSalnikov OGKovtunova LMfalseParahydrogen-Induced Polarization of Diethyl Ether Anesthetic.The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear spin hyperpolarized gas as a contrast agent. The long gas-phase lifetimes of hyperpolarized ¹²⁹ Xe make this inhalable contrast agent acceptable for clinical research today despite limitations such as high cost, low throughput of production and challenges of ¹²⁹ Xe imaging on clinical MRI scanners, which are normally equipped with proton detection only. We report on low-cost and high-throughput preparation of proton-hyperpolarized diethyl ether, which can be potentially employed for pulmonary imaging with a nontoxic, simple, and sensitive overall strategy using proton detection commonly available on all clinical MRI scanners. Diethyl ether is hype2020-01-01T00:00:00Z2020 Oct2025-04-04T01:43:01.212Z2025-04-04T01:43:01.212ZS-EPMC77222033266768710.1002/chem.202002528