biostudies-literatureUnknown8(12)Lu KYAntidiabetic properties of red yeast rice, bitter gourd, and chromium have gained scientific support. This study aimed to test whether a nutraceutical combination of these 3 materials prevented dedifferentiation of pancreatic β cells. Male db/db mice (8 weeks of age) were allocated into four groups (DB, DB/L, DB/M, and DB/H; <i>n</i> = 8-10) and fed a high-fat diet containing 0%, 0.2%, 0.4%, or 1% nutraceutical, respectively, whereas wild-type mice receiving a standard diet served as a healthy control (C; <i>n</i> = 10). The nutraceutical contained 10 mg/g monacolin K, 165 µg/g chromium, and 300 mg/g bitter gourd. After 8-weeks dietary treatment, diabetic syndromes (including hyperglycemia, hyperphagia, excessive drinking, polyuria, glucosuria, albuminuria, and glucose intolerance), were iFood science & nutrition6718-6726https://www.ebi.ac.uk/biostudies/studies/S-EPMC7723183biostudies-literatureAn antidiabetic nutraceutical combination of red yeast rice (<i>Monascus purpureus</i>), bitter gourd (<i>Momordica charantia</i>), and chromium alleviates dedifferentiation of pancreatic β cells in db/db mice.PMC7723183Lu KYLin YSWu HPChao PMChen SHfalseAn antidiabetic nutraceutical combination of red yeast rice (<i>Monascus purpureus</i>), bitter gourd (<i>Momordica charantia</i>), and chromium alleviates dedifferentiation of pancreatic β cells in db/db mice.Antidiabetic properties of red yeast rice, bitter gourd, and chromium have gained scientific support. This study aimed to test whether a nutraceutical combination of these 3 materials prevented dedifferentiation of pancreatic β cells. Male db/db mice (8 weeks of age) were allocated into four groups (DB, DB/L, DB/M, and DB/H; <i>n</i> = 8-10) and fed a high-fat diet containing 0%, 0.2%, 0.4%, or 1% nutraceutical, respectively, whereas wild-type mice receiving a standard diet served as a healthy control (C; <i>n</i> = 10). The nutraceutical contained 10 mg/g monacolin K, 165 µg/g chromium, and 300 mg/g bitter gourd. After 8-weeks dietary treatment, diabetic syndromes (including hyperglycemia, hyperphagia, excessive drinking, polyuria, glucosuria, albuminuria, and glucose intolerance), were i2020-01-01T00:00:00Z2020 Dec2026-07-16T10:22:31.366Z2021-02-20T15:08:03ZS-EPMC77231833331255510.1002/fsn3.1966