{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(21)"],"submitter":["Achterberg FB"],"pubmed_abstract":["<h4>Background</h4>Almost a third of the resections in patients with colorectal liver metastases (CRLM) undergoing curative surgery, end up being tumor-margin positive (≤1 mm margin). Near-infrared fluorescent (NIRF) imaging using the fluorescent contrast agent indocyanine green (ICG) has been studied for many different applications. When administered in a relatively low dose (10 mg) 24 hours prior to surgery, ICG accumulated in hepatocytes surrounding the CRLM. This results in the formation of a characteristic fluorescent 'rim' surrounding CRLM when located at the periphery of the liver. By resecting the metastasis with the entire surrounding fluorescent rim, in real-time guided by NIRF imaging, the surgeon can effectively acquire margin-negative (>1 mm) resections. This pilot study aims "],"journal":["Annals of translational medicine"],"pagination":["1448"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7723628"],"repository":["biostudies-literature"],"pubmed_title":["Real-time surgical margin assessment using ICG-fluorescence during laparoscopic and robot-assisted resections of colorectal liver metastases."],"pmcid":["PMC7723628"],"pubmed_authors":["Hartgrink HH","Park SM","Swijnenburg RJ","Sibinga Mulder BG","Meijer RPJ","Zlitni A","Achterberg FB","Mieog JSD","Farina Sarasqueta A","Bonsing BA","Vahrmeijer AL"],"additional_accession":[]},"is_claimable":false,"name":"Real-time surgical margin assessment using ICG-fluorescence during laparoscopic and robot-assisted resections of colorectal liver metastases.","description":"<h4>Background</h4>Almost a third of the resections in patients with colorectal liver metastases (CRLM) undergoing curative surgery, end up being tumor-margin positive (≤1 mm margin). Near-infrared fluorescent (NIRF) imaging using the fluorescent contrast agent indocyanine green (ICG) has been studied for many different applications. When administered in a relatively low dose (10 mg) 24 hours prior to surgery, ICG accumulated in hepatocytes surrounding the CRLM. This results in the formation of a characteristic fluorescent 'rim' surrounding CRLM when located at the periphery of the liver. By resecting the metastasis with the entire surrounding fluorescent rim, in real-time guided by NIRF imaging, the surgeon can effectively acquire margin-negative (>1 mm) resections. This pilot study aims ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-04T23:46:31.857Z","creation":"2025-04-04T23:46:31.857Z"},"accession":"S-EPMC7723628","cross_references":{"pubmed":["33313193"],"doi":["10.21037/atm-20-1999"]}}