{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(21)"],"submitter":["van Loon LM"],"pubmed_abstract":["Background
The upstream pressure for venous return (VR) is considered to be a combined conceptual blood pressure of the systemic vessels: the mean systemic filling pressure (MSFP). The relevance of estimating the MSFP during dynamic changes of the circulation at the bedside is controversial. Herein, we studied the effect of high ventilatory pressures on the relationship between VR and central venous pressure (CVP).Methods
In 9 healthy pigs under anaesthesia and mechanically ventilated, MSFP was estimated from extrapolated VR versus CVP relationships during inspiratory hold maneuvers (IHMs) with different levels of ventilatory pressure (Pvent). MSFP was measure 3 times per animal during euvolemia and hypovolemia. Hypovolemia was induced by bleeding with 10 mL/kg. The estimat"],"journal":["Annals of translational medicine"],"pagination":["1390"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7723632"],"repository":["biostudies-literature"],"pubmed_title":["The inspiration hold maneuver is a reliable method to assess mean systemic filling pressure but its clinical value remains unclear."],"pmcid":["PMC7723632"],"pubmed_authors":["Veltink PH","van der Hoeven H","van Loon LM","Lemson J"],"additional_accession":[]},"is_claimable":false,"name":"The inspiration hold maneuver is a reliable method to assess mean systemic filling pressure but its clinical value remains unclear.","description":"Background
The upstream pressure for venous return (VR) is considered to be a combined conceptual blood pressure of the systemic vessels: the mean systemic filling pressure (MSFP). The relevance of estimating the MSFP during dynamic changes of the circulation at the bedside is controversial. Herein, we studied the effect of high ventilatory pressures on the relationship between VR and central venous pressure (CVP).Methods
In 9 healthy pigs under anaesthesia and mechanically ventilated, MSFP was estimated from extrapolated VR versus CVP relationships during inspiratory hold maneuvers (IHMs) with different levels of ventilatory pressure (Pvent). MSFP was measure 3 times per animal during euvolemia and hypovolemia. Hypovolemia was induced by bleeding with 10 mL/kg. The estimat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-04T23:46:50.934Z","creation":"2025-04-04T23:46:50.934Z"},"accession":"S-EPMC7723632","cross_references":{"pubmed":["33313135"],"doi":["10.21037/atm-20-3540"]}}