{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Romano A"],"funding":["Associazione Italiana per la Ricerca sul Cancro"],"pagination":["8735-8746"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7724487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(23)"],"pubmed_abstract":["<h4>Background</h4>The neutrophil to lymphocyte ratio (NLR) and the lymphocyte to monocyte ratio (LMR) can reflect both the myeloid dysfunction and T-cell immune suppression and have prognostic significance.<h4>Methods</h4>In 771 newly diagnosed advanced-stage Hodgkin Lymphoma (HL) patients we evaluated the baseline values of NLR and LMR as predictors of clinical outcome. According to the multicenter prospective phase II GITIL-HD0607 trial, all patients received two ABVD courses and if PET-2 negative received four additional ABVD cycles while if PET-2-positive patients were randomized to either BEACOPP escalated (Be) plus BEACOPP baseline (Bb) (4 + 4 courses) or Be + Bb (4 + 4) and Rituximab. PET scans were centrally reviewed by an expert panel by Blinded Independent Central Review.<h4>Res"],"journal":["Cancer medicine"],"pubmed_title":["The neutrophil to lymphocyte ratio (NLR) and the presence of large nodal mass are independent predictors of early response: A subanalysis of the prospective phase II PET-2-adapted HD0607 trial."],"pmcid":["PMC7724487"],"funding_grant_id":["IG2013"],"pubmed_authors":["Biggi A","Zanotti R","Trentin L","Gini G","Gallamini A","Patti C","Corradini P","Schiavotto C","Cantonetti M","Tarella C","Picardi M","Gavarotti P","Bolis S","Viero P","Massimo Gianni A","Cimminiello M","Chauvie S","Rossi A","Di Raimondo F","La Nasa G","Viviani S","Zoli V","Rambaldi A","Romano A","Pavoni C","Parvis G","Ferreri AJM"],"additional_accession":[]},"is_claimable":false,"name":"The neutrophil to lymphocyte ratio (NLR) and the presence of large nodal mass are independent predictors of early response: A subanalysis of the prospective phase II PET-2-adapted HD0607 trial.","description":"<h4>Background</h4>The neutrophil to lymphocyte ratio (NLR) and the lymphocyte to monocyte ratio (LMR) can reflect both the myeloid dysfunction and T-cell immune suppression and have prognostic significance.<h4>Methods</h4>In 771 newly diagnosed advanced-stage Hodgkin Lymphoma (HL) patients we evaluated the baseline values of NLR and LMR as predictors of clinical outcome. According to the multicenter prospective phase II GITIL-HD0607 trial, all patients received two ABVD courses and if PET-2 negative received four additional ABVD cycles while if PET-2-positive patients were randomized to either BEACOPP escalated (Be) plus BEACOPP baseline (Bb) (4 + 4 courses) or Be + Bb (4 + 4) and Rituximab. PET scans were centrally reviewed by an expert panel by Blinded Independent Central Review.<h4>Res","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-05-03T05:05:33.607Z","creation":"2021-02-20T10:55:05Z"},"accession":"S-EPMC7724487","cross_references":{"pubmed":["33155754"],"doi":["10.1002/cam4.3396"]}}