biostudies-literatureUnknown15(12)Stens NAWhilst both cardiac output (CO) and total peripheral resistance (TPR) determine mean arterial blood pressure (MAP), their relative importance in the pressor response to isometric exercise remains unclear. This study aimed to elucidate the relative importance of these two different factors by examining pressor responses during cardiopulmonary unloading leading to step-wise reductions in CO. Hemodynamics were investigated in 11 healthy individuals before, during and after two-minute isometric exercise during lower body negative pressure (LBNP; -20mmHg and -40mmHg). The blood pressure response to isometric exercise was similar during normal and reduced preload, despite a step-wise reduction in CO during LBNP (-20mmHg and -40mmHg). During -20mmHg LBNP, the decreased stroke volume, and consequePloS onee0243627https://www.ebi.ac.uk/biostudies/studies/S-EPMC7725372biostudies-literatureFactors mediating the pressor response to isometric muscle contraction: An experimental study in healthy volunteers during lower body negative pressure.PMC7725372Sharma AThijssen DHJHisdal JKaur NBakke EFStens NAHoiseth LOStranden EfalseFactors mediating the pressor response to isometric muscle contraction: An experimental study in healthy volunteers during lower body negative pressure.Whilst both cardiac output (CO) and total peripheral resistance (TPR) determine mean arterial blood pressure (MAP), their relative importance in the pressor response to isometric exercise remains unclear. This study aimed to elucidate the relative importance of these two different factors by examining pressor responses during cardiopulmonary unloading leading to step-wise reductions in CO. Hemodynamics were investigated in 11 healthy individuals before, during and after two-minute isometric exercise during lower body negative pressure (LBNP; -20mmHg and -40mmHg). The blood pressure response to isometric exercise was similar during normal and reduced preload, despite a step-wise reduction in CO during LBNP (-20mmHg and -40mmHg). During -20mmHg LBNP, the decreased stroke volume, and conseque2020-01-01T00:00:00Z20202025-04-25T20:47:21.134Z2025-04-06T08:29:07.186ZS-EPMC77253723329641010.1371/journal.pone.0243627