biostudies-literatureLee HJHallym University Research FundNational Research Foundation of KoreaSickkids Foundation21526https://www.ebi.ac.uk/biostudies/studies/S-EPMC7726152biostudies-literatureUnknown10(1)Potentially neuroprotective effects of CI use were studied in 22 children with single sided deafness (SSD). Auditory-evoked EEG confirmed strengthened representation of the intact ear in the ipsilateral auditory cortex at initial CI activation in children with early-onset SSD (n = 15) and late-onset SSD occurring suddenly in later childhood/adolescence (n = 7). In early-onset SSD, representation of the hearing ear decreased with chronic CI experience and expected lateralization to the contralateral auditory cortex from the CI increased with longer daily CI use. In late-onset SSD, abnormally high activity from the intact ear in the ipsilateral cortex reduced, but responses from the deaf ear weakened despite CI use. Results suggest that: (1) cortical reorganization driven by unilateral heariScientific reportsConsistent and chronic cochlear implant use partially reverses cortical effects of single sided deafness in children.PMC77261522016R1A2B4016330Polonenko MJCushing SLSmieja DLee HJGordon KAPapsin BCfalseConsistent and chronic cochlear implant use partially reverses cortical effects of single sided deafness in children.Potentially neuroprotective effects of CI use were studied in 22 children with single sided deafness (SSD). Auditory-evoked EEG confirmed strengthened representation of the intact ear in the ipsilateral auditory cortex at initial CI activation in children with early-onset SSD (n = 15) and late-onset SSD occurring suddenly in later childhood/adolescence (n = 7). In early-onset SSD, representation of the hearing ear decreased with chronic CI experience and expected lateralization to the contralateral auditory cortex from the CI increased with longer daily CI use. In late-onset SSD, abnormally high activity from the intact ear in the ipsilateral cortex reduced, but responses from the deaf ear weakened despite CI use. Results suggest that: (1) cortical reorganization driven by unilateral heari2020-01-01T00:00:00Z2020 Dec2025-04-06T23:14:33.177Z2025-04-06T23:14:33.177ZS-EPMC77261523329898710.1038/s41598-020-78371-6