{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Betari N"],"funding":["Stiftelsen Kristian Gerhard Jebsen","Norges Forskningsråd","Horizon 2020 Framework Programme","Knut och Alice Wallenbergs Stiftelse","Federación Española de Enfermedades Raras"],"pagination":["593416"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7726444"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation. 5-HT synthesis is catalyzed by tryptophan hydroxylase (TPH) which exists as two distinct isoforms; TPH1 and TPH2, which are responsible for peripheral and central 5-HT, respectively. Due to the implication of 5-HT in a number of pathologies, including depression, anxiety, autism, sexual dysfunction, irritable bowel syndrome, inflammatory bowel disease, and carcinoid syndrome, there has been a growing interest in finding modulators of these enzymes in recent years. We thus performed high-throughput screening (HTS) using a fluorescence-based thermal shift assay (DSF) to search th"],"journal":["Frontiers in pharmacology"],"pubmed_title":["Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole-<i>In Vitro</i> and <i>In Vivo</i> Investigations."],"pmcid":["PMC7726444"],"funding_grant_id":["501100005416","667302","SKGJ-MED02","SAF2017-87349-R","501100004063"],"pubmed_authors":["Godoy-Marin H","Betari N","Ciruela F","Morato X","Sahlholm K","Teigen K","Jauregui O","Haavik J"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole-<i>In Vitro</i> and <i>In Vivo</i> Investigations.","description":"Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation. 5-HT synthesis is catalyzed by tryptophan hydroxylase (TPH) which exists as two distinct isoforms; TPH1 and TPH2, which are responsible for peripheral and central 5-HT, respectively. Due to the implication of 5-HT in a number of pathologies, including depression, anxiety, autism, sexual dysfunction, irritable bowel syndrome, inflammatory bowel disease, and carcinoid syndrome, there has been a growing interest in finding modulators of these enzymes in recent years. We thus performed high-throughput screening (HTS) using a fluorescence-based thermal shift assay (DSF) to search th","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-05-02T06:31:05.827Z","creation":"2021-02-20T16:45:59Z"},"accession":"S-EPMC7726444","cross_references":{"pubmed":["33324221"],"doi":["10.3389/fphar.2020.593416"]}}