{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":51,"searchCount":0},"additional":{"submitter":["Tzolos E"],"funding":["British Heart Foundation","Medical Research Council","NHLBI NIH HHS","Wellcome Trust"],"pagination":["126-135"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7728624"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["<h4>Background</h4>We aimed to establish the observer repeatability and interscan reproducibility of coronary <sup>18</sup>F-sodium-fluoride positron emission tomography (PET) uptake using a novel semi-automated approach, coronary microcalcification activity (CMA).<h4>Methods</h4>Patients with multivessel coronary artery disease underwent repeated hybrid PET and computed tomography angiography (CTA) imaging (PET/CTA). CMA was defined as the integrated standardized uptake values (SUV) in the entire coronary tree exceeding 2 standard deviations above the background SUV. Coefficients of repeatability between the same observer (intraobserver repeatability), between 2 observers (interobserver repeatability) and coefficient of reproducibility between 2 scans (interscan reproducibility), were determined at vessel and patient level.<h4>Results</h4>In 19 patients, CMA was assessed twice in 43 coronary vessels on two PET/CT scans performed 12 ± 5 days apart. There was excellent intraclass correlation for intraobserver and interobserver repeatability as well as interscan reproducibility (all ≥ 0.991). There was 100% intraobserver, interobserver and interscan agreement for the presence (CMA > 0) or absence (CMA = 0) of coronary<sup>18</sup>F-NaF uptake. Mean CMA was 3.12 ± 0.62 with coefficients of repeatability of ≤ 10% for all measures: intraobserver 0.24 and 0.22, interobserver 0.30 and 0.29 and interscan 0.33 and 0.32 at a per-vessel and per-patient level, respectively.<h4>Conclusions</h4>CMA is a repeatable and reproducible global measure of coronary atherosclerotic activity."],"journal":["Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology"],"pubmed_title":["Observer repeatability and interscan reproducibility of 18F-sodium fluoride coronary microcalcification activity."],"pmcid":["PMC7728624"],"funding_grant_id":["G0701127","RG/16/10/32375","CH/09/002/26360","MR/T005459/1","103782/Z/14/Z","FS/14/78/31020","R01 HL135557"],"pubmed_authors":["Joshi N","Kwiecinski J","van Beek EJR","Tzolos E","Lassen ML","Berman DS","Cadet S","Dey D","Moss AJ","Newby DE","Adamson PD","Dweck MR","Williams MC","Slomka PJ"],"view_count":["51"],"additional_accession":[]},"is_claimable":false,"name":"Observer repeatability and interscan reproducibility of 18F-sodium fluoride coronary microcalcification activity.","description":"<h4>Background</h4>We aimed to establish the observer repeatability and interscan reproducibility of coronary <sup>18</sup>F-sodium-fluoride positron emission tomography (PET) uptake using a novel semi-automated approach, coronary microcalcification activity (CMA).<h4>Methods</h4>Patients with multivessel coronary artery disease underwent repeated hybrid PET and computed tomography angiography (CTA) imaging (PET/CTA). CMA was defined as the integrated standardized uptake values (SUV) in the entire coronary tree exceeding 2 standard deviations above the background SUV. Coefficients of repeatability between the same observer (intraobserver repeatability), between 2 observers (interobserver repeatability) and coefficient of reproducibility between 2 scans (interscan reproducibility), were determined at vessel and patient level.<h4>Results</h4>In 19 patients, CMA was assessed twice in 43 coronary vessels on two PET/CT scans performed 12 ± 5 days apart. There was excellent intraclass correlation for intraobserver and interobserver repeatability as well as interscan reproducibility (all ≥ 0.991). There was 100% intraobserver, interobserver and interscan agreement for the presence (CMA > 0) or absence (CMA = 0) of coronary<sup>18</sup>F-NaF uptake. Mean CMA was 3.12 ± 0.62 with coefficients of repeatability of ≤ 10% for all measures: intraobserver 0.24 and 0.22, interobserver 0.30 and 0.29 and interscan 0.33 and 0.32 at a per-vessel and per-patient level, respectively.<h4>Conclusions</h4>CMA is a repeatable and reproducible global measure of coronary atherosclerotic activity.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2024-10-15T00:18:43.304Z","creation":"2022-02-11T16:20:19.98Z"},"accession":"S-EPMC7728624","cross_references":{"pubmed":["32529531"],"doi":["10.1007/s12350-020-02221-1"]}}