{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(22)"],"submitter":["Zhu Z"],"pubmed_abstract":["<h4>Background</h4>Gastric cancer (GC) is a heterogeneous disease, and is a leading cause of cancer deaths in Eastern Asia. Genomic analysis, such as whole-exome sequencing (WES), can help identify key genetic alterations leading to the malignancy and diversity of GC, and may help identify new drug targets.<h4>Methods</h4>We identified genomic alterations in a cohort of 38 GC patients, including 26 metastatic and 12 non-metastatic patients. We analyzed the association between novel gene mutations and copy number variations (CNVs) with tumor metastasis and patient survival.<h4>Results</h4>A number of significantly mutated genes in somatic and germline cells were identified. Among them, <i>ATAD3B</i> somatic mutation, a potential biomarker of immunotherapy in stomach cancers, was associated "],"journal":["Annals of translational medicine"],"pagination":["1484"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7729362"],"repository":["biostudies-literature"],"pubmed_title":["Whole-exome sequencing identifies prognostic mutational signatures in gastric cancer."],"pmcid":["PMC7729362"],"pubmed_authors":["Shi M","Cha W","Zhu Z","Dai C","Fu H","Wang S","You Q","Wang G","Wang W","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"Whole-exome sequencing identifies prognostic mutational signatures in gastric cancer.","description":"<h4>Background</h4>Gastric cancer (GC) is a heterogeneous disease, and is a leading cause of cancer deaths in Eastern Asia. Genomic analysis, such as whole-exome sequencing (WES), can help identify key genetic alterations leading to the malignancy and diversity of GC, and may help identify new drug targets.<h4>Methods</h4>We identified genomic alterations in a cohort of 38 GC patients, including 26 metastatic and 12 non-metastatic patients. We analyzed the association between novel gene mutations and copy number variations (CNVs) with tumor metastasis and patient survival.<h4>Results</h4>A number of significantly mutated genes in somatic and germline cells were identified. Among them, <i>ATAD3B</i> somatic mutation, a potential biomarker of immunotherapy in stomach cancers, was associated ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-04T23:46:44.876Z","creation":"2025-04-04T23:46:44.876Z"},"accession":"S-EPMC7729362","cross_references":{"pubmed":["33313229"],"doi":["10.21037/atm-20-6620"]}}