biostudies-literatureUnknown8(22)Zhu Z<h4>Background</h4>Gastric cancer (GC) is a heterogeneous disease, and is a leading cause of cancer deaths in Eastern Asia. Genomic analysis, such as whole-exome sequencing (WES), can help identify key genetic alterations leading to the malignancy and diversity of GC, and may help identify new drug targets.<h4>Methods</h4>We identified genomic alterations in a cohort of 38 GC patients, including 26 metastatic and 12 non-metastatic patients. We analyzed the association between novel gene mutations and copy number variations (CNVs) with tumor metastasis and patient survival.<h4>Results</h4>A number of significantly mutated genes in somatic and germline cells were identified. Among them, <i>ATAD3B</i> somatic mutation, a potential biomarker of immunotherapy in stomach cancers, was associated Annals of translational medicine1484https://www.ebi.ac.uk/biostudies/studies/S-EPMC7729362biostudies-literatureWhole-exome sequencing identifies prognostic mutational signatures in gastric cancer.PMC7729362Shi MCha WZhu ZDai CFu HWang SYou QWang GWang WYu XfalseWhole-exome sequencing identifies prognostic mutational signatures in gastric cancer.<h4>Background</h4>Gastric cancer (GC) is a heterogeneous disease, and is a leading cause of cancer deaths in Eastern Asia. Genomic analysis, such as whole-exome sequencing (WES), can help identify key genetic alterations leading to the malignancy and diversity of GC, and may help identify new drug targets.<h4>Methods</h4>We identified genomic alterations in a cohort of 38 GC patients, including 26 metastatic and 12 non-metastatic patients. We analyzed the association between novel gene mutations and copy number variations (CNVs) with tumor metastasis and patient survival.<h4>Results</h4>A number of significantly mutated genes in somatic and germline cells were identified. Among them, <i>ATAD3B</i> somatic mutation, a potential biomarker of immunotherapy in stomach cancers, was associated 2020-01-01T00:00:00Z2020 Nov2025-04-04T23:46:44.876Z2025-04-04T23:46:44.876ZS-EPMC77293623331322910.21037/atm-20-6620