{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(22)"],"submitter":["Wan Q"],"pubmed_abstract":["<h4>Background</h4>Our prior studies have shown that inflammation may play an important triggering role during the process of denervated muscle atrophy. The nonsteroidal anti-inflammatory drug aspirin exhibits the effect of anti-inflammatory factors. This study will investigate the protective effect of aspirin on denervated muscle atrophy and the underlying mechanism.<h4>Methods</h4>Mouse models of denervated muscle atrophy were established. The protective effect of aspirin (20 mg/kg/d, i.p.) on denervated muscle atrophy was analyzed using the wet weight ratio of tibialis anterior (TA) muscle and muscle fiber cross-sectional area (CSA). The levels of inflammatory factors were detected using quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. "],"journal":["Annals of translational medicine"],"pagination":["1524"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7729378"],"repository":["biostudies-literature"],"pubmed_title":["Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1α axis and STAT3 signaling."],"pmcid":["PMC7729378"],"pubmed_authors":["Yang X","Wan Q","Zhu J","Huang Z","Zhang H","Law BY","Gu J","Zhang L","Xu H","Shen Y","Sun H"],"additional_accession":[]},"is_claimable":false,"name":"Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1α axis and STAT3 signaling.","description":"<h4>Background</h4>Our prior studies have shown that inflammation may play an important triggering role during the process of denervated muscle atrophy. The nonsteroidal anti-inflammatory drug aspirin exhibits the effect of anti-inflammatory factors. This study will investigate the protective effect of aspirin on denervated muscle atrophy and the underlying mechanism.<h4>Methods</h4>Mouse models of denervated muscle atrophy were established. The protective effect of aspirin (20 mg/kg/d, i.p.) on denervated muscle atrophy was analyzed using the wet weight ratio of tibialis anterior (TA) muscle and muscle fiber cross-sectional area (CSA). The levels of inflammatory factors were detected using quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-04T23:46:51.568Z","creation":"2025-04-04T23:46:51.568Z"},"accession":"S-EPMC7729378","cross_references":{"pubmed":["33313269"],"doi":["10.21037/atm-20-5460"]}}