{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(22)"],"submitter":["Xie C"],"pubmed_abstract":["<h4>Background</h4>Rheumatoid arthritis (RA) is a systemic disease characterized by chronic synovial infiltration and proliferation, cartilage destruction, and joint injury. Ginkgolide B (GB) is an extract of the leaves of Ginkgo biloba, and pharmacological studies have shown that it has anti-inflammatory and anti-apoptotic activities. The purpose of this study was to investigate the anti-RA properties of GB.<h4>Methods</h4><i>In vivo</i>, we established a collagen II-induced arthritis (CIA) mouse model. Mice were divided into five groups (n=10): sham, CIA, GB (10 µM), GB (20 µM), and GB (40 µM). We measured arthritis score, synovial histopathological change, and peripheral blood cytokine levels. <i>In vitro</i>, we used lipopolysaccharide (LPS)-induced-fibroblast-like synoviocytes (RA-FLS"],"journal":["Annals of translational medicine"],"pagination":["1497"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7729381"],"repository":["biostudies-literature"],"pubmed_title":["Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation."],"pmcid":["PMC7729381"],"pubmed_authors":["Jiang J","Liu J","Yuan G","Zhao Z","Xie C"],"additional_accession":[]},"is_claimable":false,"name":"Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation.","description":"<h4>Background</h4>Rheumatoid arthritis (RA) is a systemic disease characterized by chronic synovial infiltration and proliferation, cartilage destruction, and joint injury. Ginkgolide B (GB) is an extract of the leaves of Ginkgo biloba, and pharmacological studies have shown that it has anti-inflammatory and anti-apoptotic activities. The purpose of this study was to investigate the anti-RA properties of GB.<h4>Methods</h4><i>In vivo</i>, we established a collagen II-induced arthritis (CIA) mouse model. Mice were divided into five groups (n=10): sham, CIA, GB (10 µM), GB (20 µM), and GB (40 µM). We measured arthritis score, synovial histopathological change, and peripheral blood cytokine levels. <i>In vitro</i>, we used lipopolysaccharide (LPS)-induced-fibroblast-like synoviocytes (RA-FLS","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-19T23:41:14.765Z","creation":"2025-04-19T23:41:14.765Z"},"accession":"S-EPMC7729381","cross_references":{"pubmed":["33313242"],"doi":["10.21037/atm-20-6420"]}}