{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(23)"],"submitter":["Fernandes MJG"],"pubmed_abstract":["Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a propyl chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were later subjected to epoxidation conditions to give the corresponding oxiranes. All derivatives were evaluated against their effect upon the viability of insect cell line Sf9 (Spodoptera frugiperda), demonstrating that structural changes elicit marked effects in terms of potency. In addition, the most promising molecules were evaluated for their impact in cell morphology, caspase-like activity, "],"journal":["International journal of molecular sciences"],"pagination":["E9257"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7729565"],"repository":["biostudies-literature"],"pubmed_title":["New Eugenol Derivatives with Enhanced Insecticidal Activity."],"pmcid":["PMC7729565"],"pubmed_authors":["Castanheira EMS","Pereira DM","Fernandes MJG","Fortes AG","Goncalves MST","Pereira RB"],"additional_accession":[]},"is_claimable":false,"name":"New Eugenol Derivatives with Enhanced Insecticidal Activity.","description":"Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a propyl chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were later subjected to epoxidation conditions to give the corresponding oxiranes. All derivatives were evaluated against their effect upon the viability of insect cell line Sf9 (Spodoptera frugiperda), demonstrating that structural changes elicit marked effects in terms of potency. In addition, the most promising molecules were evaluated for their impact in cell morphology, caspase-like activity, ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-27T00:04:22.562Z","creation":"2025-04-06T17:41:47.33Z"},"accession":"S-EPMC7729565","cross_references":{"pubmed":["33291666"],"doi":["10.3390/ijms21239257"]}}