{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McCarter SJ"],"funding":["NCATS NIH HHS","FDA HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["1462-1466"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7729983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(8)"],"pubmed_abstract":["<h4>Background</h4>Multiple system atrophy (MSA) is a neurodegenerative disorder from α-synuclein aggregation. in vitro studies suggest vitamin B12 may interrupt α-synuclein-mediated neurodegeneration. The objective of this study was to determine whether serum vitamin B12 level at MSA diagnosis is associated with survival.<h4>Methods</h4>One hundred eighty-two MSA patients evaluated at Mayo Clinic with vitamin B12 testing were studied. We determined the risk of death in relationship to serum vitamin B12 levels at MSA diagnosis, adjusting for predictors of poor survival.<h4>Results</h4>Predictors of shorter survival included vitamin B12 < 367 ng/L (HR, 1.8; 95% CI, 1.3-2.7), falls within 3 years of MSA diagnosis (HR, 1.6; 95% CI, 1.1-2.3), bladder symptoms (HR, 1.6; 95% CI, 1.0-2.6), urinary catheter requirement (HR, 1.7; 95% CI, 1.0-2.8), male sex (HR, 1.4; 95% CI, 1.0-2.0), and MSA-P subtype (HR, 1.5; 95% CI, 1.0-2.0).<h4>Conclusions</h4>Low vitamin B12 levels are associated with shorter survival in MSA. Additional studies to explore this observation and assess the potential role of vitamin B12 as a modifiable survival factor are needed. © 2020 International Parkinson and Movement Disorder Society."],"journal":["Movement disorders : official journal of the Movement Disorder Society"],"pubmed_title":["Lower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter Survival."],"pmcid":["PMC7729983"],"funding_grant_id":["P01NS44233, U54NS065736, K23NS075141, R01 FD004789","UL1 TR000135","U54 NS065736","K23 NS075141","P01 NS044233","R01 NS092625","R01 FD004789"],"pubmed_authors":["St Louis EK","Bower JH","McCarter SJ","Low P","Sandroni P","Coon EA","Singer W","Savica R","Benarroch EE"],"additional_accession":[]},"is_claimable":false,"name":"Lower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter Survival.","description":"<h4>Background</h4>Multiple system atrophy (MSA) is a neurodegenerative disorder from α-synuclein aggregation. in vitro studies suggest vitamin B12 may interrupt α-synuclein-mediated neurodegeneration. The objective of this study was to determine whether serum vitamin B12 level at MSA diagnosis is associated with survival.<h4>Methods</h4>One hundred eighty-two MSA patients evaluated at Mayo Clinic with vitamin B12 testing were studied. We determined the risk of death in relationship to serum vitamin B12 levels at MSA diagnosis, adjusting for predictors of poor survival.<h4>Results</h4>Predictors of shorter survival included vitamin B12 < 367 ng/L (HR, 1.8; 95% CI, 1.3-2.7), falls within 3 years of MSA diagnosis (HR, 1.6; 95% CI, 1.1-2.3), bladder symptoms (HR, 1.6; 95% CI, 1.0-2.6), urinary catheter requirement (HR, 1.7; 95% CI, 1.0-2.8), male sex (HR, 1.4; 95% CI, 1.0-2.0), and MSA-P subtype (HR, 1.5; 95% CI, 1.0-2.0).<h4>Conclusions</h4>Low vitamin B12 levels are associated with shorter survival in MSA. Additional studies to explore this observation and assess the potential role of vitamin B12 as a modifiable survival factor are needed. © 2020 International Parkinson and Movement Disorder Society.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-04T02:39:12.409Z","creation":"2025-02-19T00:41:53.53Z"},"accession":"S-EPMC7729983","cross_references":{"pubmed":["32320519"],"doi":["10.1002/mds.28070"]}}