{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(23)"],"submitter":["Seo S"],"pubmed_abstract":["Epilepsy is a chronic neurological disorder characterized by the recurrence of seizures. One-third of patients with epilepsy may not respond to antiseizure drugs. We aimed to examine whether D-limonene, a cyclic monoterpene, exhibited any antiseizure activity in the pentylenetetrazole (PTZ)-induced kindling mouse model and in vitro. PTZ kindling mouse model was established by administering PTZ (30 mg/kg) intraperitoneally to mice once every 48 h. We performed immunoblot blots, immunohistochemistry (IHC), and high-performance liquid chromatography (HPLC) analysis after the behavioral study. An acute injection of PTZ (60 mg/kg) induced seizure in mice, while pretreatment with D-limonene inhibited PTZ-induced seizure. Repeated administration of PTZ (30 mg/kg) increased the seizure score gradu"],"journal":["International journal of molecular sciences"],"pagination":["E9277"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7730947"],"repository":["biostudies-literature"],"pubmed_title":["D-limonene Inhibits Pentylenetetrazole-Induced Seizure via Adenosine A2A Receptor Modulation on GABAergic Neuronal Activity."],"pmcid":["PMC7730947"],"pubmed_authors":["Yun J","Seo S","Gu SM","Hong JT","Cha HJ","Min HK","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"D-limonene Inhibits Pentylenetetrazole-Induced Seizure via Adenosine A2A Receptor Modulation on GABAergic Neuronal Activity.","description":"Epilepsy is a chronic neurological disorder characterized by the recurrence of seizures. One-third of patients with epilepsy may not respond to antiseizure drugs. We aimed to examine whether D-limonene, a cyclic monoterpene, exhibited any antiseizure activity in the pentylenetetrazole (PTZ)-induced kindling mouse model and in vitro. PTZ kindling mouse model was established by administering PTZ (30 mg/kg) intraperitoneally to mice once every 48 h. We performed immunoblot blots, immunohistochemistry (IHC), and high-performance liquid chromatography (HPLC) analysis after the behavioral study. An acute injection of PTZ (60 mg/kg) induced seizure in mice, while pretreatment with D-limonene inhibited PTZ-induced seizure. Repeated administration of PTZ (30 mg/kg) increased the seizure score gradu","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-25T22:50:57.24Z","creation":"2025-04-06T09:10:16.609Z"},"accession":"S-EPMC7730947","cross_references":{"pubmed":["33291789"],"doi":["10.3390/ijms21239277"]}}