{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Dupont-Lucas C"],"funding":["Société Francophone Nutrition Clinique et Métabolisme","European Regional Development Fund"],"pubmed_abstract":["Background
Pediatric Crohn's disease is characterized by a higher incidence of complicated phenotypes. Murine models help to better understand the dynamic process of intestinal fibrosis and test therapeutic interventions. Pre-pubertal models are lacking. We aimed to adapt a model of chronic colitis to pre-pubertal rats and test if a polymeric diet rich in TGF-β2 could reduce TNBS-induced intestinal inflammation and fibrosis.Methods
Colitis was induced in 20 five-week-old Sprague-Dawley male rats by weekly rectal injections of increasing doses of TNBS (90 mg/kg, 140 mg/kg and 180 mg/kg) for 3 weeks, while 10 controls received phosphate-buffered saline. Rats were anesthetized using ketamine and chlorpromazine. After first administration of TNBS, 10 rats were fed exclusively M"],"journal":["BMC gastroenterology"],"pagination":["416"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7731574"],"repository":["biostudies-literature"],"pubmed_title":["A polymeric diet rich in transforming growth factor beta 2 does not reduce inflammation in chronic 2,4,6-trinitrobenzene sulfonic acid colitis in pre-pubertal rats."],"pmcid":["PMC7731574"],"pubmed_authors":["Aziz M","Marion-Letellier R","Jarbeau M","David A","Nicol L","Dupont-Lucas C","Amamou A","Savoye G","Colasse E","Savoye-Collet C","Bole-Feysot C","Pala M","Guerin C"],"additional_accession":[]},"is_claimable":false,"name":"A polymeric diet rich in transforming growth factor beta 2 does not reduce inflammation in chronic 2,4,6-trinitrobenzene sulfonic acid colitis in pre-pubertal rats.","description":"Background
Pediatric Crohn's disease is characterized by a higher incidence of complicated phenotypes. Murine models help to better understand the dynamic process of intestinal fibrosis and test therapeutic interventions. Pre-pubertal models are lacking. We aimed to adapt a model of chronic colitis to pre-pubertal rats and test if a polymeric diet rich in TGF-β2 could reduce TNBS-induced intestinal inflammation and fibrosis.Methods
Colitis was induced in 20 five-week-old Sprague-Dawley male rats by weekly rectal injections of increasing doses of TNBS (90 mg/kg, 140 mg/kg and 180 mg/kg) for 3 weeks, while 10 controls received phosphate-buffered saline. Rats were anesthetized using ketamine and chlorpromazine. After first administration of TNBS, 10 rats were fed exclusively M","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-04T20:04:41.442Z","creation":"2021-02-20T10:55:22Z"},"accession":"S-EPMC7731574","cross_references":{"pubmed":["33302890"],"doi":["10.1186/s12876-020-01574-8"]}}