biostudies-literatureUnknown12(19)Sotgia FThree recent papers published in Nature, Science and Cell, all present clear evidence that there is cross-reactive T-cell immunity between human coronaviruses (229E, NL63, OC43, and HKU1), linked with the common cold, and SARS-CoV-2, the causative agent of COVID-19. Can we use this information to design and build a new vaccine based on the less pathogenic, common cold coronaviruses, for the prevention of COVID-19? If we look at the history of medicine and vaccine development, from the point of view of Edward Jenner, the answer just might be yes.Aging18797-18803https://www.ebi.ac.uk/biostudies/studies/S-EPMC7732292biostudies-literatureUsing the common cold virus as a naturally occurring vaccine to prevent COVID-19: Lessons from Edward Jenner.PMC7732292Lisanti MPSotgia FfalseUsing the common cold virus as a naturally occurring vaccine to prevent COVID-19: Lessons from Edward Jenner.Three recent papers published in Nature, Science and Cell, all present clear evidence that there is cross-reactive T-cell immunity between human coronaviruses (229E, NL63, OC43, and HKU1), linked with the common cold, and SARS-CoV-2, the causative agent of COVID-19. Can we use this information to design and build a new vaccine based on the less pathogenic, common cold coronaviruses, for the prevention of COVID-19? If we look at the history of medicine and vaccine development, from the point of view of Edward Jenner, the answer just might be yes.2020-01-01T00:00:00Z2020 Oct2026-05-03T08:21:53.042Z2021-02-20T14:28:45ZS-EPMC77322923304971110.18632/aging.104166