{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuroda K"],"funding":["KAKENHI"],"pagination":["4500-4509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7734156"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(12)"],"pubmed_abstract":["Fibroblast growth factor receptor (FGFR) is associated with proliferation, migration, and angiogenesis of carcinomas, and FGFR signaling inhibitors are considered a key drug for the treatment of solid tumors with FGFR overexpression. Amplification of FGFR2 is reportedly identified in 3%-10% of gastric cancers (GCs). The aim of this study is to clarify whether the identification of the circulating tumor cells (CTCs) with FGFR2 overexpression is useful to detect patients with FGFR2-overexpressing GC. One hundred GC patients who underwent gastrectomy were enrolled. A total volume of 8 mL of peripheral blood was collected from each patient just before gastrectomy, and mononuclear cells were enriched by Ficol density gradient centrifugation. These cells were immunostained with PI/CD45/EpCAM/FGF"],"journal":["Cancer science"],"pubmed_title":["Circulating tumor cells with FGFR2 expression might be useful to identify patients with existing FGFR2-overexpressing tumor."],"pmcid":["PMC7734156"],"funding_grant_id":["23390329","18H02883"],"pubmed_authors":["Sugimoto A","Kushiyama S","Sera T","Yamamoto Y","Yashiro M","Nishimura S","Okuno T","Kuroda K","Miki Y","Togano S","Ohira M"],"additional_accession":[]},"is_claimable":false,"name":"Circulating tumor cells with FGFR2 expression might be useful to identify patients with existing FGFR2-overexpressing tumor.","description":"Fibroblast growth factor receptor (FGFR) is associated with proliferation, migration, and angiogenesis of carcinomas, and FGFR signaling inhibitors are considered a key drug for the treatment of solid tumors with FGFR overexpression. Amplification of FGFR2 is reportedly identified in 3%-10% of gastric cancers (GCs). The aim of this study is to clarify whether the identification of the circulating tumor cells (CTCs) with FGFR2 overexpression is useful to detect patients with FGFR2-overexpressing GC. One hundred GC patients who underwent gastrectomy were enrolled. A total volume of 8 mL of peripheral blood was collected from each patient just before gastrectomy, and mononuclear cells were enriched by Ficol density gradient centrifugation. These cells were immunostained with PI/CD45/EpCAM/FGF","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-05-31T23:54:05.019Z","creation":"2021-02-20T14:29:37Z"},"accession":"S-EPMC7734156","cross_references":{"pubmed":["32946655"],"doi":["10.1111/cas.14654"]}}