{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Zhao Y"],"funding":["Deutsche Forschungsgemeinschaft","Radiumhemmets Forskningsfonder","Karolinska Institutet","Barncancerfonden","Vetenskapsr?det"],"pubmed_abstract":["Late diagnosis and refractory behavior toward current treatment protocols make pancreatic ductal adenocarcinoma (PDAC) one of the most difficult cancer forms to treat. The imaging-based approach plays an important role to identify potentially curable PDAC patients in high-risk groups at the early stage. In the present study, we developed a core-shell structured gold nanorod (AuNR) as a contrast agent for multimodal imaging and investigated its application for PDAC diagnosis. The composite nanoparticles composed of a AuNR core inside a layer of mesoporous silica that was then coated with a gadolinium oxide carbonate shell (AuNR-SiO2-Gd) are designed to be used in magnetic resonance imaging (MRI), X-ray computed tomography (CT), and photoacoustic imaging (PAI). A phantom study with the AuNR-"],"journal":["ACS applied materials & interfaces"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7735668"],"repository":["biostudies-literature"],"pubmed_title":["Multimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents."],"pmcid":["PMC7735668"],"funding_grant_id":["2018-02377","PR2017-0083","161082","2017-00741","EXC 2056/390715994"],"pubmed_authors":["Parak WJ","Hassan M","Oerther S","Muhammed M","Zheng W","He R","Zhao Y","Li X","Heuchel R","El-Sayed R","Brismar TB","Feliu N","Ye F","Dutta J"],"additional_accession":[]},"is_claimable":false,"name":"Multimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents.","description":"Late diagnosis and refractory behavior toward current treatment protocols make pancreatic ductal adenocarcinoma (PDAC) one of the most difficult cancer forms to treat. The imaging-based approach plays an important role to identify potentially curable PDAC patients in high-risk groups at the early stage. In the present study, we developed a core-shell structured gold nanorod (AuNR) as a contrast agent for multimodal imaging and investigated its application for PDAC diagnosis. The composite nanoparticles composed of a AuNR core inside a layer of mesoporous silica that was then coated with a gadolinium oxide carbonate shell (AuNR-SiO2-Gd) are designed to be used in magnetic resonance imaging (MRI), X-ray computed tomography (CT), and photoacoustic imaging (PAI). A phantom study with the AuNR-","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-18T14:11:58.945Z","creation":"2025-04-07T00:13:00.466Z"},"accession":"S-EPMC7735668","cross_references":{"pubmed":["33201660"],"doi":["10.1021/acsami.0c15430"]}}