biostudies-literatureUnknownZhao YDeutsche ForschungsgemeinschaftRadiumhemmets ForskningsfonderKarolinska InstitutetBarncancerfondenVetenskapsr?detLate diagnosis and refractory behavior toward current treatment protocols make pancreatic ductal adenocarcinoma (PDAC) one of the most difficult cancer forms to treat. The imaging-based approach plays an important role to identify potentially curable PDAC patients in high-risk groups at the early stage. In the present study, we developed a core-shell structured gold nanorod (AuNR) as a contrast agent for multimodal imaging and investigated its application for PDAC diagnosis. The composite nanoparticles composed of a AuNR core inside a layer of mesoporous silica that was then coated with a gadolinium oxide carbonate shell (AuNR-SiO2-Gd) are designed to be used in magnetic resonance imaging (MRI), X-ray computed tomography (CT), and photoacoustic imaging (PAI). A phantom study with the AuNR-ACS applied materials & interfaceshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC7735668biostudies-literatureMultimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents.PMC77356682018-02377PR2017-00831610822017-00741EXC 2056/390715994Parak WJHassan MOerther SMuhammed MZheng WHe RZhao YLi XHeuchel REl-Sayed RBrismar TBFeliu NYe FDutta JfalseMultimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents.Late diagnosis and refractory behavior toward current treatment protocols make pancreatic ductal adenocarcinoma (PDAC) one of the most difficult cancer forms to treat. The imaging-based approach plays an important role to identify potentially curable PDAC patients in high-risk groups at the early stage. In the present study, we developed a core-shell structured gold nanorod (AuNR) as a contrast agent for multimodal imaging and investigated its application for PDAC diagnosis. The composite nanoparticles composed of a AuNR core inside a layer of mesoporous silica that was then coated with a gadolinium oxide carbonate shell (AuNR-SiO2-Gd) are designed to be used in magnetic resonance imaging (MRI), X-ray computed tomography (CT), and photoacoustic imaging (PAI). A phantom study with the AuNR-2020-01-01T00:00:00Z2020 Nov2025-04-18T14:11:58.945Z2025-04-07T00:13:00.466ZS-EPMC77356683320166010.1021/acsami.0c15430