biostudies-literatureUnknown11Niu JNational Natural Science Foundation of ChinaNatural Science Foundation of Guangdong ProvinceThe present study investigated the potential mechanisms of astaxanthin in the regulation of gastrointestinal immunity and retinal mitochondrial function of golden pompano (<i>Trachinotus ovatus</i>). Triplicate groups of juvenile <i>T. ovatus</i> (mean initial weight: 6.03 ± 0.01 g) were fed one of six diets (D1, D2, D3, D4, D5, and D6) for 8 weeks, with each diet containing various concentrations of astaxanthin (0, 0.0005, 0.001, 0.005, 0.01, or 0.1%, respectively). Growth performance of fish fed the D2-D5 diets was higher than that of fish fed the D1 diet; however, growth performance and survival of fish deteriorated sharply in fish fed the D6 diet. Gut villus in fish fed the D2-D5 diets were significantly longer and wider than that of fish fed the D6 diet. Feeding with D2-D5 diets led tFrontiers in physiology568462https://www.ebi.ac.uk/biostudies/studies/S-EPMC7736049biostudies-literatureDual-Function Analysis of Astaxanthin on Golden Pompano (<i>Trachinotus ovatus</i>) and Its Role in the Regulation of Gastrointestinal Immunity and Retinal Mitochondrial Dysfunction Under Hypoxia Conditions.PMC7736049Lu DQNiu JZhao WHe XSFang HHLiao SYXie JJfalseDual-Function Analysis of Astaxanthin on Golden Pompano (<i>Trachinotus ovatus</i>) and Its Role in the Regulation of Gastrointestinal Immunity and Retinal Mitochondrial Dysfunction Under Hypoxia Conditions.The present study investigated the potential mechanisms of astaxanthin in the regulation of gastrointestinal immunity and retinal mitochondrial function of golden pompano (<i>Trachinotus ovatus</i>). Triplicate groups of juvenile <i>T. ovatus</i> (mean initial weight: 6.03 ± 0.01 g) were fed one of six diets (D1, D2, D3, D4, D5, and D6) for 8 weeks, with each diet containing various concentrations of astaxanthin (0, 0.0005, 0.001, 0.005, 0.01, or 0.1%, respectively). Growth performance of fish fed the D2-D5 diets was higher than that of fish fed the D1 diet; however, growth performance and survival of fish deteriorated sharply in fish fed the D6 diet. Gut villus in fish fed the D2-D5 diets were significantly longer and wider than that of fish fed the D6 diet. Feeding with D2-D5 diets led t2020-01-01T00:00:00Z20202026-04-07T21:34:18.163Z2021-02-20T16:51:59ZS-EPMC77360493333548510.3389/fphys.2020.568462