{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Webb CA"],"funding":["NCCIH NIH HHS","NIMH NIH HHS","National Institute of Mental Health"],"pagination":["377-387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7736484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(3)"],"pubmed_abstract":["<h4>Objective</h4>Understanding the fluctuating emotional and cognitive states of adolescents with depressive symptoms requires fine-grained and naturalistic measurements. This study used ecological momentary assessment (EMA) to investigate the affective correlates and consequences of mind-wandering in adolescents with anhedonia (AH) and typically developing (TD) controls. In addition, we examined the association between mind-wandering and resting state functional connectivity between the medial prefrontal cortex (mPFC), a core hub of the default mode network (DMN) linked to internally oriented mentation, and networks linked to attentional control (dorsal attention network [DAN]) and affect/salience detection (salience network [SN]).<h4>Method</h4>A total of 65 adolescents, aged 12 to 18 years (TD = 36; AH = 29), completed a resting state functional magnetic resonance imaging scan and subsequently used a smartphone application for ecological momentary assessment (EMA) data collection (2-3 times/d for 5 days). Each survey (N = 678) prompted adolescents to report on their current positive and negative affect (PA and NA), cognition, and activity.<h4>Results</h4>The frequency of mind-wandering was higher for AH (70.0% of EMA samples) relative to TD (59.2%) participants, and the participants with AH were more likely to mind-wander to unpleasant content. Mind-wandering was associated with higher concurrent NA, even when controlling for plausible confounds (eg, current activity, social companion, rumination). Time-lagged analyses revealed a bidirectional association between mind-wandering and PA. Greater levels of mind-wandering within the AH group were associated with stronger mPFC-SN/DAN connectivity.<h4>Conclusion</h4>Rates of mind-wandering were high, especially among adolescents with anhedonia, and predicted worse affect. The relation between mind-wandering and enhanced mPFC-SN coupling may reflect heightened bottom-up influence of affective and sensory salience on DMN-mediated internally oriented thought."],"journal":["Journal of the American Academy of Child and Adolescent Psychiatry"],"pubmed_title":["Mind-Wandering in Adolescents Predicts Worse Affect and Is Linked to Aberrant Default Mode Network-Salience Network Connectivity."],"pmcid":["PMC7736484"],"funding_grant_id":["K23 MH122668","K23 MH108752","R37 MH068376","R01 MH116969","R01 AT011002"],"pubmed_authors":["Israel ES","Forbes EE","Webb CA","Pizzagalli DA","Appleman L","Belleau E"],"additional_accession":[]},"is_claimable":false,"name":"Mind-Wandering in Adolescents Predicts Worse Affect and Is Linked to Aberrant Default Mode Network-Salience Network Connectivity.","description":"<h4>Objective</h4>Understanding the fluctuating emotional and cognitive states of adolescents with depressive symptoms requires fine-grained and naturalistic measurements. This study used ecological momentary assessment (EMA) to investigate the affective correlates and consequences of mind-wandering in adolescents with anhedonia (AH) and typically developing (TD) controls. In addition, we examined the association between mind-wandering and resting state functional connectivity between the medial prefrontal cortex (mPFC), a core hub of the default mode network (DMN) linked to internally oriented mentation, and networks linked to attentional control (dorsal attention network [DAN]) and affect/salience detection (salience network [SN]).<h4>Method</h4>A total of 65 adolescents, aged 12 to 18 years (TD = 36; AH = 29), completed a resting state functional magnetic resonance imaging scan and subsequently used a smartphone application for ecological momentary assessment (EMA) data collection (2-3 times/d for 5 days). Each survey (N = 678) prompted adolescents to report on their current positive and negative affect (PA and NA), cognition, and activity.<h4>Results</h4>The frequency of mind-wandering was higher for AH (70.0% of EMA samples) relative to TD (59.2%) participants, and the participants with AH were more likely to mind-wander to unpleasant content. Mind-wandering was associated with higher concurrent NA, even when controlling for plausible confounds (eg, current activity, social companion, rumination). Time-lagged analyses revealed a bidirectional association between mind-wandering and PA. Greater levels of mind-wandering within the AH group were associated with stronger mPFC-SN/DAN connectivity.<h4>Conclusion</h4>Rates of mind-wandering were high, especially among adolescents with anhedonia, and predicted worse affect. The relation between mind-wandering and enhanced mPFC-SN coupling may reflect heightened bottom-up influence of affective and sensory salience on DMN-mediated internally oriented thought.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T02:24:29.813Z","creation":"2025-04-04T02:24:29.813Z"},"accession":"S-EPMC7736484","cross_references":{"pubmed":["32553785"],"doi":["10.1016/j.jaac.2020.03.010"]}}