{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hollenberg AM"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","Musculoskeletal Transplant Foundation","NIAMS NIH HHS","Orthopaedic Research and Education Foundation"],"pagination":["2432-2443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7736558"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(12)"],"pubmed_abstract":["Cellular bioenergetics is a promising new therapeutic target in aging, cancer, and diabetes because these pathologies are characterized by a shift from oxidative to glycolytic metabolism. We have previously reported such glycolytic shift in aged bone as a major contributor to bone loss in mice. We and others also showed the importance of oxidative phosphorylation (OxPhos) for osteoblast differentiation. It is therefore reasonable to propose that stimulation of OxPhos will have bone anabolic effect. One strategy widely used in cancer research to stimulate OxPhos is inhibition of glycolysis. In this work, we aimed to evaluate the safety and efficacy of pharmacological inhibition of glycolysis to stimulate OxPhos and promote osteoblast bone-forming function and bone anabolism. We tested a ran"],"journal":["Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research"],"pubmed_title":["Lactate Dehydrogenase Inhibition With Oxamate Exerts Bone Anabolic Effect."],"pmcid":["PMC7736558"],"funding_grant_id":["R21 AR07928","R21 AR070928","P30 AR069655","P30 AR069655- 5278","R01 AR070613","P30 AR069655‐ 5278","R01 AR072601"],"pubmed_authors":["Smith CO","Awad H","Shum LC","Eliseev RA","Hollenberg AM"],"additional_accession":[]},"is_claimable":false,"name":"Lactate Dehydrogenase Inhibition With Oxamate Exerts Bone Anabolic Effect.","description":"Cellular bioenergetics is a promising new therapeutic target in aging, cancer, and diabetes because these pathologies are characterized by a shift from oxidative to glycolytic metabolism. We have previously reported such glycolytic shift in aged bone as a major contributor to bone loss in mice. We and others also showed the importance of oxidative phosphorylation (OxPhos) for osteoblast differentiation. It is therefore reasonable to propose that stimulation of OxPhos will have bone anabolic effect. One strategy widely used in cancer research to stimulate OxPhos is inhibition of glycolysis. In this work, we aimed to evaluate the safety and efficacy of pharmacological inhibition of glycolysis to stimulate OxPhos and promote osteoblast bone-forming function and bone anabolism. We tested a ran","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-19T08:14:03.896Z","creation":"2025-04-19T08:14:03.896Z"},"accession":"S-EPMC7736558","cross_references":{"pubmed":["32729639"],"doi":["10.1002/jbmr.4142"]}}