biostudies-literatureLi FScience and Technology Program of Sichuan ProvinceProgram Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research SystemNational Key Research Program during the 13st Five-year Plan Period of ChinaBreeding Project during the 13st Five-year Plan Period of Sichuan Province910-918https://www.ebi.ac.uk/biostudies/studies/S-EPMC7738707biostudies-literatureUnknown6(4)Porcine epidemic diarrhoea virus (PEDV) belongs to the family Coronavirus, a genus of coronavirus, a highly contact-infectious intestinal disease pathogen. In this study, we downloaded 62 PEDV S gene sequences uploaded to GenBank, including 10 uploaded by our laboratory from 2018, and constructed a PEDV S gene evolution tree using MEGA V7.0 software. Phylogenetic tree analysis indicated that the genogroup of PEDV in Sichuan Province was divided into three coexisting genogroups (GII-a, GII-b and GI-a), of them, GII-a has become the main genogroup in the province due to its prevalence and range of spread. Amino acid sequence analysis showed that there were amino acid insertions and deletions in the S protein encoded by the amplified S gene, and there were amino acid mutations in the COE and SS6 of the epitope in the amplified S protein. These results provide a basic research theory for understanding the prevalence of PEDV variation and controlling PED in Sichuan.Veterinary medicine and scienceGenetic variations in S gene of porcine epidemic diarrhoea virus from 2018 in Sichuan Province, China.PMC77387072016NYZ0052CARS-SVDIP2015NZ00722018YFD0500802Zhu LLi FJiang CZeng YZhang RXu ZPeng KfalseGenetic variations in S gene of porcine epidemic diarrhoea virus from 2018 in Sichuan Province, China.Porcine epidemic diarrhoea virus (PEDV) belongs to the family Coronavirus, a genus of coronavirus, a highly contact-infectious intestinal disease pathogen. In this study, we downloaded 62 PEDV S gene sequences uploaded to GenBank, including 10 uploaded by our laboratory from 2018, and constructed a PEDV S gene evolution tree using MEGA V7.0 software. Phylogenetic tree analysis indicated that the genogroup of PEDV in Sichuan Province was divided into three coexisting genogroups (GII-a, GII-b and GI-a), of them, GII-a has become the main genogroup in the province due to its prevalence and range of spread. Amino acid sequence analysis showed that there were amino acid insertions and deletions in the S protein encoded by the amplified S gene, and there were amino acid mutations in the COE and SS6 of the epitope in the amplified S protein. These results provide a basic research theory for understanding the prevalence of PEDV variation and controlling PED in Sichuan.2020-01-01T00:00:00Z2020 Nov2024-11-12T15:15:46.505Z2021-02-20T14:29:39ZS-EPMC77387073288590810.1002/vms3.326