{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Meyer-Arndt L"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft"],"pubmed_abstract":["<h4>Background</h4>Multiple sclerosis (MS) is characterized by two neuropathological key aspects: inflammation and neurodegeneration. Clinical studies support a prospective link between psychological stress and subsequent inflammatory disease activity. However, it is unknown if a similar link exists for grey matter (GM) degeneration as the key driver of irreversible disability.<h4>Methods</h4>We tested whether neural network activity triggered in a psychological fMRI stress paradigm (a mental arithmetic task including social evaluation) conducted at a baseline time point predicts future GM atrophy in 25 persons with MS (14 females). Atrophy was determined between the baseline and a follow-up time point with a median delay of 1012 (Rg: 717-1439) days. Additionally, atrophy was assessed in 2"],"journal":["Neurobiology of stress"],"pagination":["100244"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7739031"],"repository":["biostudies-literature"],"pubmed_title":["Blunted neural and psychological stress processing predicts future grey matter atrophy in multiple sclerosis."],"pmcid":["PMC7739031"],"pubmed_authors":["Meyer-Arndt L","Scheel M","Hetzer S","Haynes JD","Engel AK","Weygandt M","Stellmann JP","Heesen C","Asseyer S","Brandt AU","Bellmann-Strobl J","Gold SM","Paul F"],"additional_accession":[]},"is_claimable":false,"name":"Blunted neural and psychological stress processing predicts future grey matter atrophy in multiple sclerosis.","description":"<h4>Background</h4>Multiple sclerosis (MS) is characterized by two neuropathological key aspects: inflammation and neurodegeneration. Clinical studies support a prospective link between psychological stress and subsequent inflammatory disease activity. However, it is unknown if a similar link exists for grey matter (GM) degeneration as the key driver of irreversible disability.<h4>Methods</h4>We tested whether neural network activity triggered in a psychological fMRI stress paradigm (a mental arithmetic task including social evaluation) conducted at a baseline time point predicts future GM atrophy in 25 persons with MS (14 females). Atrophy was determined between the baseline and a follow-up time point with a median delay of 1012 (Rg: 717-1439) days. Additionally, atrophy was assessed in 2","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-07-16T02:17:17.506Z","creation":"2025-04-06T12:57:21.782Z"},"accession":"S-EPMC7739031","cross_references":{"pubmed":["33344700"],"doi":["10.1016/j.ynstr.2020.100244"]}}