{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1"],"submitter":["Fleischmann C"],"pubmed_abstract":["<b>Objectives:</b> To examine the supplementation effects of the xanthophyll carotenoid Astaxanthin on physical performance and exertional heat strain in humans. <b>Design:</b> A randomized double blind placebo controlled trial. <b>Methods:</b> Twenty two male participants (Age: 23.14 ± 3.5 y, height: 175 ± 6 cm, body mass: 69.6 ± 8.7 kg, % body fat: 16.8 ± 3.8) received placebo (PLA, <i>n</i> = 10) or Astaxanthin (ATX, <i>n</i> = 12) 12 mg/day Per os (P.O), for 30 days, and were tested pre and post-supplementation with a maximal oxygen uptake (VO<sub>2</sub> Max) test and the heat tolerance test (HTT) (2 h walk at 40°C, 40% relative humidity (RH), 5 kph, 2% incline). NIH database registration no. NCT02088242. Gas exchange, Heart rate (HR), Relative perceived exertion (RPE), and blood lactate were measured during the VO<sub>2</sub> Max test. Heart rate (HR), rectal (Trec), and skin (Tskin) temperatures, RPE, and sweat rate (SR) were monitored in the HTT. Serum heat shock protein 72 (HSP72), Creatine phospho-kinase (CPK), C-reactive protein (CRP), and lipid profile were measured before and after the test. <b>Results:</b> The rise in blood lactate caused by the VO<sub>2</sub> Max test was significantly diminished in the ATX group (9.4 ± 3.1 and 13.0 ± 3.1 mmole<sup>*</sup>l<sup>-1</sup> in the ATX and PLA groups, respectively <i>P</i> < 0.02), as was the change in oxygen uptake during recovery (-2.02 ± 0.64 and 0.83 ± 0.79% of VO<sub>2</sub> Max in the ATX and PLA group, respectively, <i>p</i> = 0.001). No significant differences were observed in the anaerobic threshold or VO<sub>2</sub> Max. In the HTT, no significant physiological or biochemical differences were observed (HR <120 bpm, Trec rose by ~1°C to <38°C, no difference in SR). <b>Conclusions:</b> Astaxanthin supplementation improved exercise recovery. No benefit was observed for ATX over PLA in response to heat stress. Further examination of Astaxanthin in higher exertional heat strain is required."],"journal":["Frontiers in sports and active living"],"pagination":["17"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7739736"],"repository":["biostudies-literature"],"pubmed_title":["Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans."],"pmcid":["PMC7739736"],"pubmed_authors":["Fleischmann C","Raz H","Horowitz M","Heled Y","Yanovich R"],"additional_accession":[]},"is_claimable":false,"name":"Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans.","description":"<b>Objectives:</b> To examine the supplementation effects of the xanthophyll carotenoid Astaxanthin on physical performance and exertional heat strain in humans. <b>Design:</b> A randomized double blind placebo controlled trial. <b>Methods:</b> Twenty two male participants (Age: 23.14 ± 3.5 y, height: 175 ± 6 cm, body mass: 69.6 ± 8.7 kg, % body fat: 16.8 ± 3.8) received placebo (PLA, <i>n</i> = 10) or Astaxanthin (ATX, <i>n</i> = 12) 12 mg/day Per os (P.O), for 30 days, and were tested pre and post-supplementation with a maximal oxygen uptake (VO<sub>2</sub> Max) test and the heat tolerance test (HTT) (2 h walk at 40°C, 40% relative humidity (RH), 5 kph, 2% incline). NIH database registration no. NCT02088242. Gas exchange, Heart rate (HR), Relative perceived exertion (RPE), and blood lactate were measured during the VO<sub>2</sub> Max test. Heart rate (HR), rectal (Trec), and skin (Tskin) temperatures, RPE, and sweat rate (SR) were monitored in the HTT. Serum heat shock protein 72 (HSP72), Creatine phospho-kinase (CPK), C-reactive protein (CRP), and lipid profile were measured before and after the test. <b>Results:</b> The rise in blood lactate caused by the VO<sub>2</sub> Max test was significantly diminished in the ATX group (9.4 ± 3.1 and 13.0 ± 3.1 mmole<sup>*</sup>l<sup>-1</sup> in the ATX and PLA groups, respectively <i>P</i> < 0.02), as was the change in oxygen uptake during recovery (-2.02 ± 0.64 and 0.83 ± 0.79% of VO<sub>2</sub> Max in the ATX and PLA group, respectively, <i>p</i> = 0.001). No significant differences were observed in the anaerobic threshold or VO<sub>2</sub> Max. In the HTT, no significant physiological or biochemical differences were observed (HR <120 bpm, Trec rose by ~1°C to <38°C, no difference in SR). <b>Conclusions:</b> Astaxanthin supplementation improved exercise recovery. No benefit was observed for ATX over PLA in response to heat stress. Further examination of Astaxanthin in higher exertional heat strain is required.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-04T10:12:02.037Z","creation":"2025-04-04T10:12:02.037Z"},"accession":"S-EPMC7739736","cross_references":{"pubmed":["33344941"],"doi":["10.3389/fspor.2019.00017"]}}