biostudies-literatureToms KMedical Research Council47-54https://www.ebi.ac.uk/biostudies/studies/S-EPMC7744492biostudies-literatureUnknown203(1)Failure to spot the signs of primary immunodeficiency (PID) often results in delayed diagnosis. Scoring systems to identify PID exist, such as the immunodeficiency disease-related (IDR) score. This research aims to analyse and improve the diagnostic sensitivity and specificity of the IDR scoring system in a small preselected group of adult patients referred to immunology with clinical suspicion of a PID. Records of all patients presenting for the first time to an adult immunology clinic in 2018 at Addenbrooke's Hospital, Cambridge, were scored using the unmodified IDR score and modified versions of it. Included records were searched for a subsequent diagnosis of PID, and the diagnostic sensitivity and specificity of the scoring systems were analysed. Of 400 patients, 213 were excluded: 141Clinical and experimental immunologyAnalysis of scoring systems for primary immunodeficiency diagnosis in adult immunology clinics.PMC7744492G0701652Kumararatne DToms KGkrania-Klotsas EfalseAnalysis of scoring systems for primary immunodeficiency diagnosis in adult immunology clinics.Failure to spot the signs of primary immunodeficiency (PID) often results in delayed diagnosis. Scoring systems to identify PID exist, such as the immunodeficiency disease-related (IDR) score. This research aims to analyse and improve the diagnostic sensitivity and specificity of the IDR scoring system in a small preselected group of adult patients referred to immunology with clinical suspicion of a PID. Records of all patients presenting for the first time to an adult immunology clinic in 2018 at Addenbrooke's Hospital, Cambridge, were scored using the unmodified IDR score and modified versions of it. Included records were searched for a subsequent diagnosis of PID, and the diagnostic sensitivity and specificity of the scoring systems were analysed. Of 400 patients, 213 were excluded: 1412021-01-01T00:00:00Z2021 Jan2026-07-16T02:19:58.148Z2021-02-20T13:43:03ZS-EPMC77444923299032510.1111/cei.13526