{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun W"],"funding":["Ministry of Science and Technology of the People&apos;s Republic of China","Ministry of Education of the People&apos;s Republic of China","National Natural Science Foundation of China","Beijing Municipal Commission of Education","Dezhou University"],"pagination":["31700-31705"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7745405"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(49)"],"pubmed_abstract":["Fluorescence detection is desirable to track the gene transfer process in order to explain the mechanism. Here, a fluorescent nanoparticle, diketopyrrolopyrrole-based liposome (<b>DPL</b>), was prepared for DNA delivery and tumor imaging <i>in vitro</i> and <i>in vivo</i>. The process to deliver DNA into cells was detected in real time by <b>DPL</b> according to the fluorescent property. The transfection efficacies (TEs) for luciferase and enhanced green fluorescent protein (EGFP) analysis of <b>DPL</b> were 1.5 times those of the commercial transfection agent <b>Lipo 2000</b>. Importantly, the <b>DPL</b>/DNA system has high EGFP TE <i>in vivo</i> with tumor targeting ability. This work provided an effective strategy for monitoring transfection processes."],"journal":["ACS omega"],"pubmed_title":["Fluorescent Nanoparticles for Targeted Tumor Imaging and DNA Tracking Gene Delivery <i>In Vitro</i>/<i>In Vivo</i>."],"pmcid":["PMC7745405"],"funding_grant_id":["21372032","2019xjrc335","2016YFE0205400-005","21778012"],"pubmed_authors":["Cui JX","Sun W","Tang F","Lu ZL"],"additional_accession":[]},"is_claimable":false,"name":"Fluorescent Nanoparticles for Targeted Tumor Imaging and DNA Tracking Gene Delivery <i>In Vitro</i>/<i>In Vivo</i>.","description":"Fluorescence detection is desirable to track the gene transfer process in order to explain the mechanism. Here, a fluorescent nanoparticle, diketopyrrolopyrrole-based liposome (<b>DPL</b>), was prepared for DNA delivery and tumor imaging <i>in vitro</i> and <i>in vivo</i>. The process to deliver DNA into cells was detected in real time by <b>DPL</b> according to the fluorescent property. The transfection efficacies (TEs) for luciferase and enhanced green fluorescent protein (EGFP) analysis of <b>DPL</b> were 1.5 times those of the commercial transfection agent <b>Lipo 2000</b>. Importantly, the <b>DPL</b>/DNA system has high EGFP TE <i>in vivo</i> with tumor targeting ability. This work provided an effective strategy for monitoring transfection processes.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-26T09:06:27.562Z","creation":"2021-02-20T16:38:31Z"},"accession":"S-EPMC7745405","cross_references":{"pubmed":["33344822"],"doi":["10.1021/acsomega.0c04213"]}}