biostudies-literatureMohammad SScott-Gentle FoundationNICHD NIH HHSNIDA NIH HHSNIMH NIH HHSNIAAA NIH HHSNational Institutes of HealthNIH HHS38https://www.ebi.ac.uk/biostudies/studies/S-EPMC7745478biostudies-literatureUnknown12(1)<h4>Background</h4>Harsh environments surrounding fetuses and children can induce cellular damage in the developing brain, increasing the risk of intellectual disability and other neurodevelopmental disorders such as schizophrenia. However, the mechanisms by which early damage leads to disease manifestation in later life remain largely unknown. Previously, we demonstrated that the activation of heat shock (HS) signaling can be utilized as a unique reporter to label the cells that undergo specific molecular/cellular changes upon exposure to environmental insults throughout the body. Since the activation of HS signaling is an acute and transient event, this approach was not intended for long-term tracing of affected cells after the activation has diminished. In the present study, we generateJournal of neurodevelopmental disordersLong-term spatial tracking of cells affected by environmental insults.PMC77454781U54HD090257-01R01AA025215R01 AA025215U54 HD090257R01 DA023999UH2AA026106UH2 AA026106R01 MH111674R01DA023999R01 AA026272R37 DA023999R01AA026272Ayvazian NMohammad STorii MPage SJSasaki TKawasawa YIHashimoto-Torii KRakic PfalseLong-term spatial tracking of cells affected by environmental insults.<h4>Background</h4>Harsh environments surrounding fetuses and children can induce cellular damage in the developing brain, increasing the risk of intellectual disability and other neurodevelopmental disorders such as schizophrenia. However, the mechanisms by which early damage leads to disease manifestation in later life remain largely unknown. Previously, we demonstrated that the activation of heat shock (HS) signaling can be utilized as a unique reporter to label the cells that undergo specific molecular/cellular changes upon exposure to environmental insults throughout the body. Since the activation of HS signaling is an acute and transient event, this approach was not intended for long-term tracing of affected cells after the activation has diminished. In the present study, we generate2020-01-01T00:00:00Z2020 Dec2025-04-22T05:33:35.694Z2025-04-05T21:22:24.878ZS-EPMC77454783332793810.1186/s11689-020-09339-w