{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Heissenberger C"],"funding":["Hochschuljubiläumsstiftung der Stadt Wien","Austrian Science Fund FWF","Mount Desert Island Biological Laboratory","Université Libre de Bruxelles","Belgian National Fund for Scientific Research","Région Wallonne (DGO6)","Région Wallonne","National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS","Herzfelder&apos;sche Familienstiftung"],"pagination":["e56205"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7746234"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we reported that NSUN-5 is responsible for depositing m<sup>5</sup>C at position C2381 on the 26S rRNA in <i>Caenorhabditis elegans</i>. Here, we show that NSUN-1 is writing the second known 26S rRNA m<sup>5</sup>C at position C2982. Depletion of <i>nsun-1</i> or <i>nsun-5</i> improved thermotolerance and slightly increased locomotion at midlife, however, only soma-specific knockdown of <i>nsun-1</i> extended lifespan. Moreover, soma-specific knockdown of <i>nsun-1</i> reduced body size and impaired fecundity, suggesting non-cell-autonomous effects. While ribosome biogenesis and global protein synthesis were unaffected by <i>nsun-1</i> deple"],"journal":["eLife"],"pubmed_title":["The ribosomal RNA m&lt;sup&gt;5&lt;/sup&gt;C methyltransferase NSUN-1 modulates healthspan and oogenesis in &lt;i&gt;Caenorhabditis elegans&lt;/i&gt;."],"pmcid":["PMC7746234"],"funding_grant_id":["H- 327123/2018","F.R.S./FNRS","P30623","W 1224","P20GM103423","grant RIBO cancer no. 1810070","1810070","P20GM104318","P40 OD010440","James L. Boyer Fellowship","P20 GM104318","I2514","P20 GM103423","P 30623","W1224"],"pubmed_authors":["Stocker I","Wacheul L","Rollins JA","Krammer TL","Grillari J","Schosserer M","Snow S","Rogers AN","Heissenberger C","Lafontaine DLJ","Tav K","Shpylovyi A","Nagelreiter F"],"additional_accession":[]},"is_claimable":false,"name":"The ribosomal RNA m&lt;sup&gt;5&lt;/sup&gt;C methyltransferase NSUN-1 modulates healthspan and oogenesis in &lt;i&gt;Caenorhabditis elegans&lt;/i&gt;.","description":"Our knowledge about the repertoire of ribosomal RNA modifications and the enzymes responsible for installing them is constantly expanding. Previously, we reported that NSUN-5 is responsible for depositing m<sup>5</sup>C at position C2381 on the 26S rRNA in <i>Caenorhabditis elegans</i>. Here, we show that NSUN-1 is writing the second known 26S rRNA m<sup>5</sup>C at position C2982. Depletion of <i>nsun-1</i> or <i>nsun-5</i> improved thermotolerance and slightly increased locomotion at midlife, however, only soma-specific knockdown of <i>nsun-1</i> extended lifespan. Moreover, soma-specific knockdown of <i>nsun-1</i> reduced body size and impaired fecundity, suggesting non-cell-autonomous effects. While ribosome biogenesis and global protein synthesis were unaffected by <i>nsun-1</i> deple","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-04-29T20:21:01.271Z","creation":"2021-02-20T15:41:40Z"},"accession":"S-EPMC7746234","cross_references":{"pubmed":["33289480"],"doi":["10.7554/eLife.56205"]}}