{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mo Q"],"funding":["European Union’s Horizon 2020 project","National Natural Science Foundation of China","National Key Research and Development Program of China","Youth Innovation Promotion Association of the Chinese Academy of Sciences"],"pagination":["e1009129"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7746268"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(12)"],"pubmed_abstract":["Bunyavirus ribonucleoprotein (RNP) that is assembled by polymerized nucleoproteins (N) coating a viral RNA and associating with a viral polymerase can be both the RNA synthesis machinery and the structural core of virions. Bunyaviral N and RNP thus could be assailable targets for host antiviral defense; however, it remains unclear which and how host factors target N/RNP to restrict bunyaviral infection. By mass spectrometry and protein-interaction analyses, we here show that host protein MOV10 targets the N proteins encoded by a group of emerging high-pathogenic representatives of bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV), one of the most dangerous pathogens listed by World Health Organization, in RNA-independent manner. MOV10 that was further shown t"],"journal":["PLoS pathogens"],"pubmed_title":["Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly."],"pmcid":["PMC7746268"],"funding_grant_id":["31870162","2018YFA0507202","653316"],"pubmed_authors":["Mo Q","Wang H","Deng F","Ning YJ","Xu Z"],"additional_accession":[]},"is_claimable":false,"name":"Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly.","description":"Bunyavirus ribonucleoprotein (RNP) that is assembled by polymerized nucleoproteins (N) coating a viral RNA and associating with a viral polymerase can be both the RNA synthesis machinery and the structural core of virions. Bunyaviral N and RNP thus could be assailable targets for host antiviral defense; however, it remains unclear which and how host factors target N/RNP to restrict bunyaviral infection. By mass spectrometry and protein-interaction analyses, we here show that host protein MOV10 targets the N proteins encoded by a group of emerging high-pathogenic representatives of bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV), one of the most dangerous pathogens listed by World Health Organization, in RNA-independent manner. MOV10 that was further shown t","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-04-29T21:30:36.444Z","creation":"2021-02-20T17:33:55Z"},"accession":"S-EPMC7746268","cross_references":{"pubmed":["33284835"],"doi":["10.1371/journal.ppat.1009129"]}}