biostudies-literatureUnknown7Sun JTBackground: Emerging studies have described and analyzed epidemiological, clinical, laboratory, and radiological features of COVID-19 patients. Yet, scarce information is available regarding the association of lipid profile features and disease severity and mortality. Methods: We conducted a prospective observational cohort study to investigate lipid profile features in patients with COVID-19. From 9 February to 4 April 2020, a total of 99 patients (31 critically ill and 20 severely ill) with confirmed COVID-19 were included in the study. Dynamic alterations in lipid profiles were recorded and tracked. Outcomes were followed up until 4 April 2020. Results: We found that high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A-1 (apoA-1) levels were significantFrontiers in cardiovascular medicine584987https://www.ebi.ac.uk/biostudies/studies/S-EPMC7746652biostudies-literatureLipid Profile Features and Their Associations With Disease Severity and Mortality in Patients With COVID-19.PMC7746652Shen LChen ZNie PGe HPu JWang WZhang MSun JTQu XLYing XYZhou YYang FfalseLipid Profile Features and Their Associations With Disease Severity and Mortality in Patients With COVID-19.Background: Emerging studies have described and analyzed epidemiological, clinical, laboratory, and radiological features of COVID-19 patients. Yet, scarce information is available regarding the association of lipid profile features and disease severity and mortality. Methods: We conducted a prospective observational cohort study to investigate lipid profile features in patients with COVID-19. From 9 February to 4 April 2020, a total of 99 patients (31 critically ill and 20 severely ill) with confirmed COVID-19 were included in the study. Dynamic alterations in lipid profiles were recorded and tracked. Outcomes were followed up until 4 April 2020. Results: We found that high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A-1 (apoA-1) levels were significant2020-01-01T00:00:00Z20202025-06-01T00:20:31.415Z2025-06-01T00:20:31.415ZS-EPMC77466523334451610.3389/fcvm.2020.584987