{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Zhang H"],"funding":["China Scholarship Council","European Association for the Study of Diabetes"],"pubmed_abstract":["<b>Aims/hypothesis:</b> Changes in cardiac metabolism and ion homeostasis precede and drive cardiac remodeling and heart failure development. We previously demonstrated that sodium/glucose cotransporter 2 inhibitors (SGLT2i's) have direct cardiac effects on ion homeostasis, possibly through inhibition of the cardiac sodium/hydrogen exchanger (NHE-1). Here, we hypothesize that Empagliflozin (EMPA) also possesses direct and acute cardiac effects on glucose and fatty acid metabolism of isolated type II diabetes mellitus (<i>db/db</i>) mouse hearts. In addition, we explore whether direct effects on glucose metabolism are nullified in the presence of an NHE-1 inhibitor. <b>Methods:</b> Langendorff-perfused type II diabetic db/db mouse hearts were examined in three different series: <b>1</b>: <s"],"journal":["Frontiers in cardiovascular medicine"],"pagination":["592233"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7746656"],"repository":["biostudies-literature"],"pubmed_title":["Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts."],"pmcid":["PMC7746656"],"pubmed_authors":["Uthman L","Bakker D","Houten SM","Sari S","Zhang H","Coronel R","Hollmann MW","Chen S","Zuurbier CJ","Weber NC","van Weeghel M"],"additional_accession":[]},"is_claimable":false,"name":"Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.","description":"<b>Aims/hypothesis:</b> Changes in cardiac metabolism and ion homeostasis precede and drive cardiac remodeling and heart failure development. We previously demonstrated that sodium/glucose cotransporter 2 inhibitors (SGLT2i's) have direct cardiac effects on ion homeostasis, possibly through inhibition of the cardiac sodium/hydrogen exchanger (NHE-1). Here, we hypothesize that Empagliflozin (EMPA) also possesses direct and acute cardiac effects on glucose and fatty acid metabolism of isolated type II diabetes mellitus (<i>db/db</i>) mouse hearts. In addition, we explore whether direct effects on glucose metabolism are nullified in the presence of an NHE-1 inhibitor. <b>Methods:</b> Langendorff-perfused type II diabetic db/db mouse hearts were examined in three different series: <b>1</b>: <s","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-06-01T00:20:31.708Z","creation":"2025-06-01T00:20:31.708Z"},"accession":"S-EPMC7746656","cross_references":{"pubmed":["33344518"],"doi":["10.3389/fcvm.2020.592233"]}}