biostudies-literatureSang YShanghai Center for Plant Stress BiologyChinese Academy of SciencesNational Natural Science Foundation of ChinaChinese 1000 Talents Program100025https://www.ebi.ac.uk/biostudies/studies/S-EPMC7747989biostudies-literatureUnknown1(4)Effector proteins delivered inside plant cells are powerful weapons for bacterial pathogens, but this exposes the pathogen to potential recognition by the plant immune system. Therefore, the effector repertoire of a given pathogen must be balanced for a successful infection. <i>Ralstonia solanacearum</i> is an aggressive pathogen with a large repertoire of secreted effectors. One of these effectors, RipE1, is conserved in most <i>R</i>. <i>solanacearum</i> strains sequenced to date. In this work, we found that RipE1 triggers immunity in <i>N</i>. <i>benthamiana</i>, which requires the immune regulator SGT1, but not EDS1 or NRCs. Interestingly, RipE1-triggered immunity induces the accumulation of salicylic acid (SA) and the overexpression of several genes encoding phenylalanine-ammonia lyasPlant communicationsIntra-strain Elicitation and Suppression of Plant Immunity by <i>Ralstonia solanacearum</i> Type-III Effectors in <i>Nicotiana benthamiana</i>.PMC7747989XDB2704020431571973Derevnina LLuo JZhuang HYu WYu GMacho APSang YWei YfalseIntra-strain Elicitation and Suppression of Plant Immunity by <i>Ralstonia solanacearum</i> Type-III Effectors in <i>Nicotiana benthamiana</i>.Effector proteins delivered inside plant cells are powerful weapons for bacterial pathogens, but this exposes the pathogen to potential recognition by the plant immune system. Therefore, the effector repertoire of a given pathogen must be balanced for a successful infection. <i>Ralstonia solanacearum</i> is an aggressive pathogen with a large repertoire of secreted effectors. One of these effectors, RipE1, is conserved in most <i>R</i>. <i>solanacearum</i> strains sequenced to date. In this work, we found that RipE1 triggers immunity in <i>N</i>. <i>benthamiana</i>, which requires the immune regulator SGT1, but not EDS1 or NRCs. Interestingly, RipE1-triggered immunity induces the accumulation of salicylic acid (SA) and the overexpression of several genes encoding phenylalanine-ammonia lyas2020-01-01T00:00:00Z2020 Jul2025-04-05T15:14:23.811Z2025-04-05T15:14:23.811ZS-EPMC77479893336724410.1016/j.xplc.2020.100025