{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen W"],"funding":["China Scholarship Council","Deutsche Forschungsgemeinschaft","Alexander von Humboldt-Stiftung","Einstein Stiftung Berlin"],"pagination":["15126-15129"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7756304"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(66)"],"pubmed_abstract":["An aldehyde with a cyclohexa-2,5-dienyl group in the α-position is introduced as a storable surrogate of highly reactive acetaldehyde. The cyclohexa-2,5-dienyl unit is compatible with an enantioselective Michael addition to nitroalkenes promoted by a Hayashi-Jørgensen catalyst and can be removed by a boron Lewis acid mediated C-C bond cleavage. The robust two-step sequence does not require a large excess of the aldehyde component that is typically needed when directly using acetaldehyde."],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["The Cyclohexa-2,5-dienyl Group as a Placeholder for Hydrogen: Organocatalytic Michael Addition of an Acetaldehyde Surrogate."],"pmcid":["PMC7756304"],"funding_grant_id":["Oe 249/18-1"],"pubmed_authors":["Fang H","Xie K","Chen W","Oestreich M"],"additional_accession":[]},"is_claimable":false,"name":"The Cyclohexa-2,5-dienyl Group as a Placeholder for Hydrogen: Organocatalytic Michael Addition of an Acetaldehyde Surrogate.","description":"An aldehyde with a cyclohexa-2,5-dienyl group in the α-position is introduced as a storable surrogate of highly reactive acetaldehyde. The cyclohexa-2,5-dienyl unit is compatible with an enantioselective Michael addition to nitroalkenes promoted by a Hayashi-Jørgensen catalyst and can be removed by a boron Lewis acid mediated C-C bond cleavage. The robust two-step sequence does not require a large excess of the aldehyde component that is typically needed when directly using acetaldehyde.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-22T21:50:45.639Z","creation":"2025-04-06T03:47:59.627Z"},"accession":"S-EPMC7756304","cross_references":{"pubmed":["32808731"],"doi":["10.1002/chem.202003764"]}}