{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(50)"],"submitter":["Mansour W"],"pubmed_abstract":["The one-pot regioselective and catalytic synthesis of bioactive chromones and flavones was achieved via phosphine-free cyclocarbonylative Sonogashira coupling reactions of 2-iodophenols with aryl alkynes, alkyl alkynes, and dialkynes. The reactions are catalyzed by new dibromidobis(NHC)palladium(II) complexes. The new bridged <i>N</i>,<i>N</i>'-substituted benzimidazolium salts (<b>L1</b>, <b>L2</b>, and <b>L3</b>) and their palladium complexes <b>C1</b>, <b>C2</b>, and <b>C3</b> were designed, prepared, and fully characterized using different physical and spectroscopic techniques. The molecular structures of complexes <b>C1</b> and <b>C3</b> were determined by single-crystal X-ray diffraction analysis. They showed a distorted square planar geometry, where the Pd(II) ion is bonded to the carbon atoms of two cis NHC carbene ligands and two cis bromido anions. These complexes displayed a high catalytic activity in cyclocarbonylative Sonogashira coupling reactions with low catalyst loadings. The regioselectivity of these reactions was controlled by using diethylamine as the base and DMF as the solvent."],"journal":["ACS omega"],"pagination":["32515-32529"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7758971"],"repository":["biostudies-literature"],"pubmed_title":["Regioselective Synthesis of Chromones via Cyclocarbonylative Sonogashira Coupling Catalyzed by Highly Active Bridged-Bis(N-Heterocyclic Carbene)Palladium(II) Complexes."],"pmcid":["PMC7758971"],"pubmed_authors":["El Ali B","Fettouhi M","Mansour W"],"additional_accession":[]},"is_claimable":false,"name":"Regioselective Synthesis of Chromones via Cyclocarbonylative Sonogashira Coupling Catalyzed by Highly Active Bridged-Bis(N-Heterocyclic Carbene)Palladium(II) Complexes.","description":"The one-pot regioselective and catalytic synthesis of bioactive chromones and flavones was achieved via phosphine-free cyclocarbonylative Sonogashira coupling reactions of 2-iodophenols with aryl alkynes, alkyl alkynes, and dialkynes. The reactions are catalyzed by new dibromidobis(NHC)palladium(II) complexes. The new bridged <i>N</i>,<i>N</i>'-substituted benzimidazolium salts (<b>L1</b>, <b>L2</b>, and <b>L3</b>) and their palladium complexes <b>C1</b>, <b>C2</b>, and <b>C3</b> were designed, prepared, and fully characterized using different physical and spectroscopic techniques. The molecular structures of complexes <b>C1</b> and <b>C3</b> were determined by single-crystal X-ray diffraction analysis. They showed a distorted square planar geometry, where the Pd(II) ion is bonded to the carbon atoms of two cis NHC carbene ligands and two cis bromido anions. These complexes displayed a high catalytic activity in cyclocarbonylative Sonogashira coupling reactions with low catalyst loadings. The regioselectivity of these reactions was controlled by using diethylamine as the base and DMF as the solvent.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2021-02-20T16:55:22Z","creation":"2021-02-20T16:55:22Z"},"accession":"S-EPMC7758971","cross_references":{"pubmed":["33376889"],"doi":["10.1021/acsomega.0c04706"]}}